24456-59-5

Basic information

• Product Name: 6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE-1-THIONE
• Synonyms: 6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE-1-THIONE;6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE-1-THIONE 99%;6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-thione,99%
• CAS NO: 24456-59-5
• Molecular Formula: C₁₁H₁₃NO₂S
• Molecular Weight: 223.29
• Mol File: 24456-59-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 223-226 °C
• Boiling Point: 354.3°Cat760mmHg
• Flash Point: 168.1°C
• Appearance: /
• Density: 1.2144 (rough estimate)
• Vapor Pressure: 3.38E-05mmHg at 25°C
• Refractive Index: 1.4790 (estimate)
• PKA: 12.08±0.20(Predicted)
• CAS DataBase Reference: 6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE-1-THIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE-1-THIONE(24456-59-5)
• EPA Substance Registry System: 6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE-1-THIONE(24456-59-5)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 37/39-26
• Hazardous Substances Data: 24456-59-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H13NO2S/c1-13-9-5-7-3-4-12-11(15)8(7)6-10(9)14-2/h5-6H,3-4H2,1-2H3,(H,12,15)

Upstream product

• 75-15-0 carbon disulfide 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 21714-25-0 4-(2-isothiocyanatoethyl)-1,2-dimethoxybenzene 
• 493-49-2 6,7-dimethoxy-3,4-dihydro-2H-isoquinolin-1-one 
• 1745-07-9 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 

Downstream Products

• 4118-36-9 6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 33033-84-0 6,7-dimethoxy-1-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydroisoquinoline 
• 15547-55-4 1-(3',4'-dimethoxyphenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 4008-69-9 6,7-dimethoxy-2-methyl-1-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 85686-86-8 C₃₁H₃₅N₅O₅ 
• 85686-84-6 C₃₂H₃₇N₅O₄ 
• 85686-80-2 C₃₂H₄₅N₅O₂ 
• 85686-78-8 C₂₆H₃₃N₅O₂ 
• 95837-03-9 9,10-dimethoxy-2-mesitylimino-3-methyl-3,4,6,7-tetrahydro-2H-1,3,5-triazino<2,1-a>isoquinolin-4-one 
• 95836-75-2 9,10-dimethoxy-2-(3,4-dimethoxyanilino)-6,7-dihydro-4H-1,3,5-triazino<2,1-a>isoquinolin-4-one 
• 85686-90-4 2-mesitylamino-9,10-dimethoxy-6,7-dihydro-4H-1,3,5-triazino<2,1-a>isoquinolin-4-one 
• 88281-79-2 9,10-dimethoxy-2-(2,4-dichloroanilino)-6,7-dihydro-4H-1,3,5-triazino<2,1-a>isoquinolin-4-one 
• 95836-74-1 9,10-dimethoxy-2-(2,4-dimethylanilino)-6,7-dihydro-4H-1,3,5-triazino<2,1-a>isoquinolin-4-one 
• 95836-70-7 9,10-dimethoxy-2-cyclohexylamino-6,7-dihydro-4H-1,3,5-triazino<2,1-a>isoquinolin-4-one 

Relevant articles and documents

Demethylative Lactonization Provides a Shortcut to High-Yielding Syntheses of Lamellarins

Modular gram-scale syntheses of the trimethyl ethers of lamellarins G (6) and D (7) were achieved from readily accessible precursors in the highest overall yields reported to date (6, six steps, 82%; 7, seven steps, 86%). A novel demethylative lactonizati

Total synthesis of racemic 1-aryl-tetrahydroisoquinoline alkaloids

A new synthetic route was developed for the preparation of natural products cryptostyline I, II, III and 1-phenyl-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline. The Liebeskind-Srogl palladium-catalyzed carbon-carbon cross-coupling protocol was use

Reactions of 1,2,3,4-Tetrahydroisoquinoline Derivatives with Sulfur

1,2,3,4-Tetrahydroisoquinolines react with sulfur in pyridine to give two different types of products, depending on the structure of the starting compounds. 1-Substituted derivatives 1 undergo partial dehydrogenation with formation of the corresponding 3,4-dihydroisoquinolines 3. 1,2,3,4-Tetrahydroisoquinolines 5 bearing no substituent in 1-position yield the 3,4-dihydro-1(2H)isoquinolinethiones 6, comprising a new and simple synthesis of compounds 6.