24456-59-5

Usage

InChI:InChI=1/C11H13NO2S/c1-13-9-5-7-3-4-12-11(15)8(7)6-10(9)14-2/h5-6H,3-4H2,1-2H3,(H,12,15)

Upstream product

• 1745-07-9 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 493-49-2 6,7-dimethoxy-3,4-dihydro-2H-isoquinolin-1-one 
• 75-15-0 carbon disulfide 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 21714-25-0 4-(2-isothiocyanatoethyl)-1,2-dimethoxybenzene 

Downstream Products

• 77670-17-8 7-β-phenoxy-2',3'-dimethoxybenzooctem 
• 77670-15-6 6-methylthio-7-phenoxy-2',3'-dimethoxybenzooctem 
• 85686-89-1 9,10-dimethoxy-2-mesitylamino-6,7-dihydro-4H-1,3,5-triazino<2,1-a>isoquinolin-4-thione 
• 95837-05-1 9,10-dimethoxy-2-mesitylimino-3-isopropyl-3,4,6,7-tetrahydro-2H-1,3,5-triazino<2,1-a>isoquinolin-4-one 
• 85686-77-7 C₂₅H₃₀N₆O₄ 
• 85686-76-6 C₂₂H₂₅N₅O₂*HI 
• 85686-74-4 C₂₄H₂₉N₅O₂*HI 
• 85686-92-6 4-ethylthio-9,10-dimethoxy-2-mesitylimino-6,7-dihydro-2H-1,3,5-triazino<2,1-a>isoquinoline hydroiodide 
• 85686-72-2 C₂₆H₃₃N₅O₄*HI 
• 85686-82-4 9,10-dimethoxy-2-mesitylimino-(4-methylanilino)-6,7-dihydro-2H-1,3,5-triazino<2,1-a>isoquinoline 
• 85686-83-5 9,10-Dimethoxy-2-mesitylimino-4-(2,4-dimethylanilino)-6,7-dihydro-2H-triazino(2,1-a)isoquinoline hydriodide 
• 95836-70-7 9,10-dimethoxy-2-cyclohexylamino-6,7-dihydro-4H-1,3,5-triazino<2,1-a>isoquinolin-4-one 
• 95836-74-1 9,10-dimethoxy-2-(2,4-dimethylanilino)-6,7-dihydro-4H-1,3,5-triazino<2,1-a>isoquinolin-4-one 
• 88281-79-2 9,10-dimethoxy-2-(2,4-dichloroanilino)-6,7-dihydro-4H-1,3,5-triazino<2,1-a>isoquinolin-4-one 

Relevant academic research and scientific papers

Demethylative Lactonization Provides a Shortcut to High-Yielding Syntheses of Lamellarins

Modular gram-scale syntheses of the trimethyl ethers of lamellarins G (6) and D (7) were achieved from readily accessible precursors in the highest overall yields reported to date (6, six steps, 82%; 7, seven steps, 86%). A novel demethylative lactonizati

Practical Decagram-Scale Synthesis of a Lamellarin Analogue and Deprotection of Lamellarin Isopropyl Ethers

Modular syntheses of naturally occurring lamellarin ε (5) and the synthetic analogue dehydrolamellarin J (6), both of them promising lead candidates for anticancer activity, were accomplished in high overall yields. Key steps in these routes are a late-st

Total synthesis of racemic 1-aryl-tetrahydroisoquinoline alkaloids

A new synthetic route was developed for the preparation of natural products cryptostyline I, II, III and 1-phenyl-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline. The Liebeskind-Srogl palladium-catalyzed carbon-carbon cross-coupling protocol was use

Aza-annulation as a versatile approach to the synthesis of non-benzodiazepene compounds for the treatment of sleep disorders

The aza-annulation of enamino ester substrates has been demonstrated as an efficient alternative to the syntheses of non-benzodiazepine sleep inducers. Enamino ester substrates derived from aryl, thiophene, and indole functionally were prepared from the c

Reactions of 1,2,3,4-Tetrahydroisoquinoline Derivatives with Sulfur

1,2,3,4-Tetrahydroisoquinolines react with sulfur in pyridine to give two different types of products, depending on the structure of the starting compounds. 1-Substituted derivatives 1 undergo partial dehydrogenation with formation of the corresponding 3,4-dihydroisoquinolines 3. 1,2,3,4-Tetrahydroisoquinolines 5 bearing no substituent in 1-position yield the 3,4-dihydro-1(2H)isoquinolinethiones 6, comprising a new and simple synthesis of compounds 6.

STEREOSPECIFIC SYNTHESIS OF SOME POLYCYCLIC CIS-β-LACTAMS

Amides 1 on reaction with P2S5 in pyridine give thioamides 2 which on treatment with methyl iodide afford the corresponding 1-methylthio-3,4-dihydroisoquinolines 3.Annelation of these imines with phenoxyacetyl chloride in the presence of triethylamine furnish 6-methylthio-7-phenoxy-2',3'-dimethoxybenzooctem 4a and 6-methylthio-7-phenoxy-2',3'-methylenedioxybenzooctem 4b respectively.Desulphurisation of these β-methylthio-β-lactams with Raney nickel yield the novel polycylic cis-β-lactams 5a and 5b.