244640-37-7

Basic information

• Product Name: 2′-(4-chlorobenzoyl)acetophenone
• Synonyms: 2′-(4-chlorobenzoyl)acetophenone
• CAS NO: 244640-37-7
• Molecular Weight: 258.704
• Mol File: 244640-37-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2′-(4-chlorobenzoyl)acetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2′-(4-chlorobenzoyl)acetophenone(244640-37-7)
• EPA Substance Registry System: 2′-(4-chlorobenzoyl)acetophenone(244640-37-7)

Safety Data

• Hazardous Substances Data: 244640-37-7(Hazardous Substances Data)

Upstream product

• 2142-70-3 2-iodoacetophenone 
• 873-76-7 para-Chlorobenzyl alcohol 
• 109495-50-3 {2-hydroxy-α-methyl-benzylidene}-{4-chloro-benzoyl}-hydrazine 
• 1240389-12-1 ((4-chlorophenyl)(2-(E)-1-methoxyiminoethyl)phenyl)methanone 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 1588511-50-5 C₁₇H₁₆N₂O₂S₂ 
• 1588511-51-6 N-methoxy-N-methyl-2-vinylbenzamide 
• 100961-61-3 2-[(benzo[d]thiazol-2-ylthio)methyl]benzoic acid 
• 7115-89-1 2-(bromomethyl)benzoic acid 
• 1588511-58-3 (4-chlorophenyl)(2-vinylphenyl)methanone 
• 536-40-3 4-chlorobenzoic acid hydrazide 
• 74-11-3 para-chlorobenzoic acid 
• 7335-27-5 ethyl 4-chlorobenzoate 

Downstream Products

• 1240389-51-8 1-(4-chlorophenyl)-4-methylphthalazine 
• 206358-21-6 3-(4-chlorophenyl)-3-hydroxy-2,3-dihydro-1H-inden-1-one 

Relevant articles and documents

Palladium-Catalyzed Direct Oxidative Coupling of Iodoarenes with Primary Alcohols Leading to Ketones: Application to the Synthesis of Benzofuranones and Indenones

In the present study, a palladium-catalyzed direct oxidative acylation through cross-dehydrogenative coupling has been investigated, utilizing readily available primary alcohols as acylating sources. Overall, this oxidative coupling proceeds via three distinct transformations such as oxidation, radical formation, and cross-coupling in one catalytic process. This protocol does not involve the assistance of a directing group or activation of the carbonyl group by any other means. Furthermore, this reaction made use of no toxic CO gas as carbonylating agent; instead, feedstock primary alcohols have been utilized as acylation source. Notably, the synthesis of benzofuranones and indenones is enabled. This strategy was also applied to the synthesis of n-butylphthalide, fenofibrate, pitofenone, and neo-lignan.

Iodine-promoted oxidative conversion of o-vinyl diaryl ketones into o-acetyl diaryl ketones, synthesis of 1-methyl-4-arylphthalazines as analogues of podophyllotoxin

A new method is described for the metal-free oxidation of o-vinyl diaryl ketones in the presence of molecular iodine or N-iodosuccinimide to give o-acetyl diaryl ketones. This transformation involves the initial formation of an iodohydrin, and the o-carbo

Pd-catalyzed ortho-C-H acylation/cross coupling of aryl ketone O-methyl oximes with aldehydes using tert-butyl hydroperoxide as oxidant

A Pd-catalyzed protocol for direct C-H bond acylation by cross coupling of aryl ketone oximes and aldehydes using tert-butyl hydroperoxide (TBHP) as oxidant was developed. With oximes as a directing group for the C-H activation, the coupling with aldehydes was achieved with remarkable regioselectivity. The acylation reactions exhibit excellent functional group tolerance, and both aliphatic and heteroaromatic aldehydes can be effectively coupled to the oximes.