7115-89-1

Usage

Uses

Used in Pharmaceutical Industry:
2-(Bromomethyl)benzoic acid is used as a synthetic intermediate for the development of pharmaceutical compounds. Its benzylic bromide and carboxylic acid functional groups enable the formation of new chemical entities through nucleophilic reactions and esterification, contributing to the creation of novel drug candidates with potential therapeutic benefits.
Used in Chemical Synthesis:
2-(Bromomethyl)benzoic acid is used as a key building block in the synthesis of various organic compounds. Its reactive functional groups facilitate the formation of new chemical bonds and the construction of complex molecular structures, which can be applied in a wide range of chemical and material science applications.
Used in Material Science:
2-(Bromomethyl)benzoic acid is used as a component in the development of new materials with specific properties. Its ability to undergo nucleophilic reactions and esterification reactions allows for the creation of materials with tailored characteristics, such as improved stability, reactivity, or selectivity, which can be utilized in various industries, including electronics, coatings, and adhesives.

InChI:InChI=1/C8H7BrO2/c9-5-6-3-1-2-4-7(6)8(10)11/h1-4H,5H2,(H,10,11)

Upstream product

• 118-90-1 ortho-methylbenzoic acid 
• 128-08-5 N-Bromosuccinimide 
• 40819-28-1 2-(bromomethyl)benzoyl bromide 
• 87-41-2 2-benzofuran-1(3H)-one 

Downstream Products

• 2417-73-4 methyl 2-bromomethylbenzoate 
• 87-41-2 2-benzofuran-1(3H)-one 
• 612-20-4 2-(hydroxymethyl)benzoic acid 
• 7115-90-4 α-Bromo-o-toluyl Chloride 
• 869623-54-1 2-bromomethyl-benzoic acid prop-2-ynyl ester 
• 1055304-08-9 2,2,2-trichloroethyl 2-(bromomethyl)benzoate 
• 935433-66-2 4-(2-methoxycarbonylbenzyl)-3-nitrobenzoic acid ethyl ester 
• 1428732-53-9 2-((di-tert-butylphosphino)methyl)benzoic acid hydrobromide 
• 74785-02-7 (2-(bromomethyl)phenyl)methanol 
• 7115-91-5 2-ethoxycarbonylbenzyl bromide 
• 7115-92-6 2-Aethoxycarbonylaminooxymethyl-benzoesaeureaethylester 
• 7116-02-1 2-Aminooxymethyl-benzoesaeureaethylester 
• 7115-93-7 2-aminooxymethyl-benzoic acid 
• 141882-87-3 2-Ethylsulfanylmethyl-benzoic acid (2S,3R,4S,5R,6R)-3,4,5-tris-benzoyloxy-6-benzoyloxymethyl-tetrahydro-pyran-2-yl ester 

Relevant academic research and scientific papers

Synthesis of 2,3-dihydro-1H-2-benzazepin-1-ones and 3H-2-benzoxepin-1-ones by isocyanide-based multicomponent reaction/Wittig sequence starting from phosphonium salt precursors

A one-pot synthesis of multisubstituted 2,3-dihydro-1H-2-benzazepin-1-ones and 3H-2-benzoxepin-1-ones by an I-MCR/Wittig sequence was developed. The reaction of phosphonium salt 3, arylglyoxals 4, amine 5 (or without), and isocyanide 6 produced the 2,3-di

Visible-Light-Mediated Late-Stage Sulfonylation of Anilines with Sulfonamides

A visible-light-mediated late-stage sulfonylation of anilines with sulfonamides under simple reaction conditions is presented. Various primary or secondary sulfonamides including several pharmaceuticals were incorporated successfully via N–S bond activati

One-Pot Synthesis of 3-(1,2,3,4-Tetrahydroisoquinolin-1-yl)-isoquinolin-1(2 H)-ones by DEAD-Promoted Oxidative Ugi-Wittig -Reaction Starting from Phosphonium Salt Precursors

A new one-pot synthesis of 3-(1,2,3,4-tetrahydroisoquinolin-1-yl)-isoquinolin-1(2H)-ones by DEAD-promoted oxidative Ugi Wittig reaction was developed. The sequential reactions of (2-carboxybenzyl)triphenylphosphonium salts, isocyanides, and N-aryl-1,2,3,4

Performance comparison of two cascade reaction models in fluorescence off-on detection of hydrogen sulfide

Comparative studies on the performances of two cascade reaction based fluorescent H2S probes are reported. These probes were also designed to address the solubility issues of existing probes. The Reso-N3 probe favors the H2S mediated azide-to-amine reduction followed by a cyclization to release the resorufin fluorophore. Reso-Br undergoes a bromide-to-thiol nucleophilic substitution followed by a similar cyclization releasing the same fluorophore. Reso-N3 exhibited lower background fluorescence and better H2S sensing behavior in water compared to Reso-Br. Reso-Br underwent hydrolysis in aqueous buffer conditions (pH = 7.4) while, Reso-N3 was quite stable. Reso-N3 displayed high selectivity and sensitivity towards H2S. Live cell imaging of the species by the probe was also established. This journal is

Phthalide: A direct building-block towards P,O and P,N hemilabile ligands. Application in the palladium-catalysed Suzuki-Miyaura cross-coupling of aryl chlorides

The direct synthesis of new hemilabile ligands from the economical, readily available lactone phthalide is described. Pd-complexes of one such ligand were found highly effective in general Suzuki-Miyaura cross-coupling reactions, including deactivated and hindered aryl chlorides. The Royal Society of Chemistry 2013.

SAR and lead optimization of an HIV-1 Vif-APOBEC3G axis inhibitor

We describe structure-activity relationship and optimization studies of RN-18, an HIV-1 Vif-APOBEC3G axis inhibitor. Targeted modifications of RN-18 ring C, ring B, ring A, bridge A-B, and bridge B-C were performed to identify the crucial structural features, which generated new inhibitors with similar (4g and 4i) and improved (5, 8b, and 11) activities. Two potent water-soluble RN-18 analogues, 17 and 19, are also disclosed, and we describe the results of pharmacological studies with compound 19. The findings described here will be useful in the development of more potent Vif inhibitors and in the design of probes to identify the target protein of RN-18 and its analogues.

N-benzyl substituted pyridyl porphyrin compounds and methods of use thereof

The present invention relates to N-Benzyl-Substituted Pyridyl Porphyrin Compounds, compositions comprising an effective amount of an N-Benzyl-Substituted Pyridyl Porphyrin Compound and methods for treating or preventing injury due to exposure to a reactiv

PYRIDYL-SUBSTITUTED PORPHYRIN COMPOUNDS AND METHODS OF USE THEREOF

The present invention relates to Pyridyl-Substituted Porphyrin Compounds, compositions comprising an effective amount of a Pyridyl-Substituted Porphyrin Compound and methods for treating or preventing injury due to exposure to a reactive species, erectile dysfunction due to surgery, lung disease, hyperoxia, neurodegenerative disease, liver disease, myocardial damage during cardioplegia, an inflammatory condition, a reperfusion injury, an ischemic condition, a cardiovascular disease, diabetes, a diabetic complication, cancer, a side effect of cancer chemotherapy, or a radiation-induced injury, or to prolong the half-life of an oxidation-prone compound, comprising administering to a subject in need thereof an effective amount of a Pyridyl-Substituted Porphyrin Compound.

Topical formulations for treating allergic diseases

Methods for topically treating allergic diseases of the eye, ear or nose using tricyclic compounds are disclosed.

An alternative method for the synthesis of γ-lactones by using cesium fluoride-celite/acetonitrile combination

A variety of 2-(1-bromoalkyl) benzoic acids 4 undergo intramolecular nucleophilic substitution reaction when treated with a CsF-Celite as solid base in acetonitrile under reflux condition to give the corresponding cyclized phthalides in moderate to very good yield. These 2-(1-bromoalkyl) benzoic acids 4 are formed by the α-bromination of 2-alkylbenzoic acids 3 using N-bromosuccinimide and a catalytic amount of α,α′ -azoisobutyronitrile in carbon tetrachloride under reflux.