2447-87-2Relevant academic research and scientific papers
Convenient metal-free direct oxidative amidation of aldehyde using dibromoisocyanuric acid under mild conditions
Kang, Soosung,La, Minh Thanh,Kim, Hee-Kwon
, p. 3541 - 3546 (2018/08/29)
A facile method for the direct synthesis of amides from aldehydes is described. Amide bonds were synthesized by an oxidative amidation in the presence of dibromoisocyanuric acid (DBI). Treatment of aromatic and aliphatic aldehydes with dibromoisocyanuric acid generated acyl bromide intermediates, which were employed to react with a variety of secondary and primary amines to give amides. Through this reaction method, various amides were synthesized directly from aldehydes under mild conditions in high yields and short times. This facile and efficient procedure provides potential strategy for the direct synthesis of amides from aldehydes.
Activation of imidazolides using methyl trifluoromethanesulfonate: A convenient method for the preparation of hindered esters and amides
Ulibarri, Gerardo,Choret, Nadege,Bigg, Dennis C. H.
, p. 1286 - 1288 (2007/10/03)
Treatment of imidazolides with methyl trifluoromethanesulfonate followed by reaction with alcohols or amines provides a convenient one-pot procedure for the preparation of esters and amides. The method is applicable to imidazolides of low reactivity as well as to hindered nucleophiles.
