24471-57-6

Basic information

• Product Name: 9-(bromomethyl)phenanthrene
• Synonyms: 9-(Bromomethyl)phenanthrene; Phenanthrene, 9-(bromomethyl)-
• CAS NO: 24471-57-6
• Molecular Formula: C₁₅H₁₁Br
• Molecular Weight: 271.1518
• Mol File: 24471-57-6.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 411.7°C at 760 mmHg
• Flash Point: 209°C
• Density: 1.448g/cm³
• Vapor Pressure: 1.3E-06mmHg at 25°C
• Refractive Index: 1.728
• CAS DataBase Reference: 9-(bromomethyl)phenanthrene(CAS DataBase Reference)
• NIST Chemistry Reference: 9-(bromomethyl)phenanthrene(24471-57-6)
• EPA Substance Registry System: 9-(bromomethyl)phenanthrene(24471-57-6)

Safety Data

• Hazardous Substances Data: 24471-57-6(Hazardous Substances Data)

Upstream product

• 833-81-8 1,2-diphenylpropene 
• 573-17-1 9-bromophenanthrene 
• 71112-64-6 9-phenanthrylmagnesium bromide 
• 37608-29-0 7,7-dichlorodibenzonorcaradiene 
• 949-41-7 1a,9b-dihydro-cyclopropa[1]phenanthrene 
• 85-01-8 phenanthrene 
• 82491-33-6 9-methylene-9,10-dihydrophenanthrene 
• 4707-72-6 9-hydroxymethylphenanthrene 
• 883-20-5 9-methylphenanthrene 
• 4707-71-5 Phenanthrene-9-carboxaldehyde 

Downstream Products

• 50781-52-7 9-(cyanomethyl)phenanthrene 
• 33895-28-2 9-Phenanthrylmethyl-triphenylphosphonium-bromid 
• 479669-08-4 2-(9-phenanthrylmethyl)cyclohexanone 
• 190-95-4 dibenzoperylene 
• 53156-65-3 trans-1-(β-Naphthyl)-2-(9-phenanthryl)-ethylen 
• 53156-66-4 dibenzochrysene 
• 15398-91-1 9-phenanthrylmethylamine 
• 111200-31-8 ethyl 2-acetyl-4-oxo-2-(9-phenanthrylmethyl)-4-phenylbutanoate 
• 98677-89-5 4-hydroxy-4-(1-propenyl)-4,5-dihydroacephenanthrylene 
• 98677-88-4 4-hydroxy-4-(2-propenyl)-4,5-dihydroacephenanthrylene 
• 98677-80-6 4-hydroxy-4,5-dihydroacephenanthrylene 
• 98677-81-7 4-(2-propenyl)acephenanthrylene 
• 98677-75-9 4-(1-propenyl)acephenanthrylene 
• 98677-79-3 4-oxo-4,5-dihydroacephenanthrylene 

Relevant articles and documents

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Design, synthesis and antitumour evaluation of pyrrolo[1,2-f]-phenanthridine and dibenzo[f,h]pyrrolo[1,2-b]isoquinoline derivatives

A series of 1,2-bis(hydroxymethyl)pyrrolo[1,2-f]phenanthridine derivatives and their alkyl (ethyl and isopropyl) carbamates and 12,13-bis(hydroxymethyl)-9,14-dihydro-dibenzo[f,h]pyrrolo[1,2-b]isoquinoline derivatives were synthesized for antiproliferative evaluation. The preliminary antitumour studies revealed that these two types of bis(hydroxymethyl) derivatives showed significant antitumour activities and were able to inhibit the growth of various human tumour cell lines in vitro. Several of the derivatives were demonstrated to cause DNA interstrand cross-links by an alkaline agarose gel shifting assay. These conjugates were cytotoxic to a variety of cancer cell lines by inducing DNA damage, delaying cell cycle progression in the G2/M phase and triggering apoptosis. Compound 21a, dissolved in a vehicle suitable for intravenous administration, was selected for antitumour studies in animal models. We demonstrated that at a dose that did not cause body weight loss in mice, compound 21a could significantly suppress the growth of tumour xenografts of human lung cancer H460 and colorectal cancer HCT-116 cells in nude mice. Our present results confirm the antitumour activities of these conjugates.

Construction of polyaromatics via photocyclization of 2-(fur-3-yl) ethenylarenes, using a 3-furyl group as an isopropenyl equivalent synthon

The construction of different types of substituted arenes was demonstrated through the photocyclization of 2-(fur-3-yl)ethenylarenes using a 3-furyl group as an isopropenyl equivalent synthon in the photocyclization reaction. The furan portion of the photocyclization intermediate could be fragmented via a base-induced elimination reaction to yield a series of substituted polyaromatics, including naphthalene, benzofuran, benzothiophene, phenanthrene, phenalene, acenaphthene, and triphenylene. Using different reagents, this method made it possible to introduce methyl or 2-hydroxyethyl groups as substituents at specific positions in these arenes.