24472-02-4

Usage

Class

Dioxolanes

Subclass

Cyclic organic compounds

Structure

Contains a five-membered 1,3-dioxolane moiety

Usage

a. Pharmaceutical and chemical industries
b. Solvent
c. Intermediate in the synthesis of other organic compounds
d. Production of fragrances and flavors

Physical state

Colorless liquid

Odor

Mild, pleasant

Flammability

Flammable

Safety precautions

Handle and store with caution due to potential health and safety hazards

InChI:InChI=1/C7H12O4/c1-3-8-7(9-4-1)10-5-2-6-11-7/h1-6H2

Upstream product

• 2032-75-9 2,2-dichloro-1,3-benzodioxole 
• 504-63-2 trimethyleneglycol 
• 1850-14-2 tetramethoxymethane 
• 78-09-1 orthocarbonic acid tetraethyl ester 
• 4885-03-4 dichlorodiphenoxymethane 
• 95104-50-0 2,2-Dimethoxy-1,3-dioxan 

Relevant academic research and scientific papers

Ein neuer Zugang zu Spiroorthocarbonaten und neuen Orthokohlensaeure-Derivaten

New and simple processes have been developed, which give in good or excellent yields new diphenoxyalkanediyldioxymethanes, symmetrical and unsymmetrical spiroorthocarbonates, spirocyclic orthothiocarbamic acid esters, and acetals of urea by successive or simultaneous substitution of chloro and phenoxy groups contained in dichlorodiphenoxymethane.

Process for producing spiro-orthocarbonate

A process for producing spiro-orthocarbonate having glycol unit (2) is described, which comprises reacting a spiro-orthocarbonate having glycol unit (1) which is different from glycol unit (2), with a glycol having glycol unit (2) to release a glycol having glycol unit (1).

Orthoamides, XXXVIII. - Contributions to the Chemistry of Orthocarbonic Acid Esters and α,α,α-Trialkoxyacetonitriles

The reactivity of the orthocarbonates 4 and the nitriles 1 has been investigated.Carboxylic acids are esterified by 4b. Orthocarbonates 4c-f and 9b are prepared by transesterification of 4b.Mixed substituted orthocarbonates 8c-f are obtained from the nitriles 1a,b.The nitriles 2a and 3a react with alkali alcoholate in alcohol to yield the orthocarbamic acid esters 13a,b. Spirocyclic orthocarbonates 17a-d are prepared from 4b and 1,2 or 1,3-dioles, respectively. The reaction of phenol with 1b affords the mixed substituted orthocarbonate 18a. Catechol is converted by 1a into the orthocarbonate 20a.Reactions of 4b with amines and ami ne derivatives are studied. In the course of these investigations guanidines 21, imidocarbonic acid esters 22a-c, 30, carbamic acid esters 25, ureas 26, the isourea derivative 29, as well as the 1,3,4-oxadiazole 31 are prepared. The mechanism of these reactions is discussed. Imidocarbonic acid esters 22d-f, 38, N-cyanocarbamates 39, and isoureas 37 can be prepared from 1b and amines or amine derivatives. 2a as well as 13b react with cyanamide to give the N-cyanoisourea 40. Ureas 26 are formed in the reaction of 1a,b with secondary amines at elevated temperatures.The guanidinium cyanide 41a can be obtained by reaction of pyrrolidine with 1b in ether, whereas under similiar conditions from 1a and pyrrolidine the amidine 42 is produced. o-Aminophenol, o-phenylenediamine and anthranilic acid are cyclized by 4b or 1b to afford the heterocyclic compounds 43-45. α- and β-amino acids are transformed by 4b or 1b into the N-(ethoxycarbonyl)amino acid esters 46 and 47, respectively.