4885-03-4

Usage

Uses

Used in Pharmaceutical Industry:
DICHLORODIPHENOXYMETHANE is used as a reactant for the cyclocondensation of aminophenols and amines, which are essential in the synthesis of various pharmaceutical compounds. This application is crucial for the development of new drugs and the improvement of existing ones.
Used in Ophthalmology:
In the field of ophthalmology, DICHLORODIPHENOXYMETHANE is used in the preparation of LIM-Kinase 2 inhibitors. These inhibitors are essential for the treatment of ocular hypertension, a condition characterized by increased pressure within the eye, which can lead to vision loss if left untreated. DDM plays a vital role in the development of these inhibitors, contributing to the advancement of eye care and the prevention of vision impairment.

Upstream product

• 102-09-0 bis(phenyl) carbonate 
• 4442-41-5 diphenoxymethane 

Downstream Products

• 4895-47-0 tetraphenoxyethene 
• 4513-75-1 tetraphenyl orthocarbonate 
• 126256-29-9 methyl 2-(benzoyloxy)-2-methylpropanoate 
• 105014-10-6 2,2-Diphenoxy-[1,3]dioxepane 
• 79463-77-7 N-cyanodiphenylcarbonimidate 
• 55849-58-6 3,9-dimethylidene-1,5,7,11-tetraoxaspiro[5.5]undecane 
• 89635-72-3 phenyl 2,2-dimethyl-3-oxopropanoate 
• 126256-26-6 phenyl camphor-3-carboxylate 
• 126256-24-4 phenyl 2-oxocyclooctanecarboxylate 
• 126256-23-3 phenyl 2-oxocycloheptanecarboxylate 
• 126256-27-7 phenyl 1-methyl-4-(1-methylvinyl)-2-oxocyclohexanecarboxylate 
• 126256-28-8 phenyl 5,5-dimethyl-3-oxo-1-cyclohexen-1-ylacetate 
• 114313-77-8 diphenyl N-sulfamoylcarbonimidate 
• 105014-08-2 5,5-Dimethyl-2,2-diphenoxy-[1,3]dioxane 

Relevant academic research and scientific papers

Novel Gonadotropin-Releasing Hormone Antagonists: Peptides Incorporating Modified Nω-Cyanoguanidino Moieties

In order to minimize the deleterious effects of histamine release resulting from the administration to rats and humans of some potent gonadotropin-releasing hormone (GnRH) antagonists, various arginine residues were replaced with the less basic Nω-cyano-Nω'-alkyl- or -arylhomoarginine, -arginine, or -p-aminophenylalanine and Nω-triazolyllysine, -ornithine or -p-aminophenylalanine residues in active analogues.These novel analogues were synthesized on a solid-phase support via a two-step modification of the Nω-NH2 of lysine, ornithine, or p-aminophenylalanineresidues in otherwise protected resin bound peptides.Most analogues were tested in the rat antiovulatory assay (AOA) and three in vitro assays: a pituitary cell culture assay, a binding assay to pituitary cell membranes, and a histamine release assay.Introduction of the cyanoguanidino and Nω-triazolyl moieties into GnRH analogues yielded several water-soluble antagonists which showed a desirable therapeutic ratio (low histamine release activity to high in vivo potency).Among them, "Azaline" (10, 1,DCpa2,DPal3,Lys5(atz),DLys6(atz),ILys8,DAla10>GnRH), inhibited ovulation in the rat by 90percent at 2 μg/rat with an ED50 in the in vitro histamine release assay comparable to that of GnRH itself.

Synthesis of Bis(aryloxy)chloromethanes via Radical-Induced Chlorinations of Formaldehyde Diaryl Acetals

Bis(aryloxy)chloromethanes 2 and bis(aryloxy)dichloromethanes 3 are prepared via radical-induced chlorinations of the formaldehyde diaryl acetals 1 with chlorine or sulfuryl chloride.

Diphenyl Cyanocarbonimidate. A Versatile Synthon for the Construction of Heterocyclic Systems

A simple high yield synthesis of diphenyl cyanocarbonimidate is reported.This synthon may be used to prepare functionalized benzimidazoles, benzoxazoles and triazoles in good yield under mild conditions.