245040-40-8

Upstream product

• 128461-58-5 (4S,5R)-4-Methyl-3-(pent-4-enoyl)-5-phenyl-1,3-oxazolidin-2-one 
• 106921-60-2 2,2-dimethyl-3-oxopentanal 

Downstream Products

• 245040-43-1 (4R,5S,6S)-2-[(4S,5R)-5-Allyl-2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-5-(tert-butyl-dimethyl-silanyloxy)-2,4,6-trimethyl-non-8-en-3-one 
• 245040-57-7 (4R,5S,6S)-2-[(4S,5R)-5-Allyl-2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-5-hydroxy-2,4,6-trimethyl-non-8-en-3-one 
• 245040-42-0 2-[(4S,5R)-5-Allyl-2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-2-methyl-pentan-3-one 

Relevant academic research and scientific papers

Design and synthesis of constrained epothilone analogs: The efficient synthesis of eleven-membered rings by olefin metathesis

The efficient synthesis of both left- and right-hand halves of a constrained analog of the anticancer natural product epothilone is described. The eleven-membered rings common to both compounds are prepared by olefin metathesis.