Design and synthesis of constrained epothilone analogs: The efficient synthesis of eleven-membered rings by olefin metathesis

DOI: 10.1016/S0040-4020(99)00301-4

Source and publish data:

Tetrahedron p. 8199 - 8214 (1999)

Update date:2022-08-04

Topics:

Authors:

Winkler, Jeffrey D.

Holland, Joanne M.

Kasparec, Jiri

Axelsen, Paul H.

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Article abstract of DOI:10.1016/S0040-4020(99)00301-4

The efficient synthesis of both left- and right-hand halves of a constrained analog of the anticancer natural product epothilone is described. The eleven-membered rings common to both compounds are prepared by olefin metathesis.

Full text of DOI:10.1016/S0040-4020(99)00301-4

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