Design and synthesis of constrained epothilone analogs: The efficient synthesis of eleven-membered rings by olefin metathesis

DOI: 10.1016/S0040-4020(99)00301-4

Source and publish data:

Tetrahedron p. 8199 - 8214 (1999)

Update date:2022-08-04

Topics:

Authors:

Winkler, Jeffrey D.

Holland, Joanne M.

Kasparec, Jiri

Axelsen, Paul H.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4020(99)00301-4

The efficient synthesis of both left- and right-hand halves of a constrained analog of the anticancer natural product epothilone is described. The eleven-membered rings common to both compounds are prepared by olefin metathesis.

Full text of DOI:10.1016/S0040-4020(99)00301-4

Products guided by the article

Product name:(2S,3S)-2-Allyl-3-hydroxy-4,4-dimethyl-1-((4S,5R)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-heptane-1,5-dione

Cas No:245040-40-8

R&D Labs maybe for 245040-40-8

Hangzhou Gangjin Chemical Co.,Ltd.(expird)

Contact:+86-571-85109780

Address:707 Zhejiang Minhang Bldg., No.290 Zhongshan North Road, Hangzhou 310003, China
JADECHEM NINGBO CO.,LTD.

Contact:+86-574-89075960

Address:#100 Xiang Yun Road, New High tech area, Ningbo, China
Jurong Huaheng Natural Biological Products Factory

website:http://www.risebiochem.com

Contact:+86-13921007726

Address:Chuncheng town,Jurong city,Jiangsu province,China
Changzhou Welton Chemical Co., Ltd,

Contact:0086-519-85910828,85920537,85912897

Address:No.8 Jinlong Road, Binjiang Park, Changzhou, Jiangsu, China.
Beijing Century Richap Chemistry Co.,Ltd

Contact:+86- 010-64455497

Address:Guannan County, Lianyungang City, Jiangsu Province, China

Relevant to this article

9-CF₃ and 13-CF₃-β-carotene, canthaxanthin and related carotenoids. Synthesis, characterization and electrochemical data

Doi:10.1016/S0022-1139(99)00045-7
(1999)
A multisubstrate adduct inhibitor of AICAR transformylase

Doi:10.1021/jm990323+
(1999)
New rhodium complexes with P,N-ligands possessing a hydroxy or methoxy group. Synthesis, characterization and application to hydroformylation of styrene

Doi:10.1016/S0022-328X(99)00181-3
(1999)
Mechanistic insights into the gold-catalyzed cycloisomerization of bromoallenyl ketones: Ligand-controlled regioselectivity

Doi:10.1021/ja802144t
(2008)
Synthesis and biochemical evaluation of 3-fluoromethyl-1,2,3,4- tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N- methyltransferase versus the α₂-adrenoceptor

Doi:10.1021/jm990045e
(1999)
On the way to unsymmetrical terpyridines carrying carboxylic acids

Doi:10.1002/jhet.5570370509
(2000)

Article Doi