2455-04-1

Basic information

• Product Name: 4-chlorobutyramide
• Synonyms: 4-chlorobutyramide;4-chlorobutanamide(SALTDATA: FREE)
• CAS NO: 2455-04-1
• Molecular Formula: C₄H₈ClNO
• Molecular Weight: 121.56542
• EINECS: 219-526-9
• Mol File: 2455-04-1.mol

Chemical Properties

• Melting Point: 99-100 °C(Solv: benzene (71-43-2))
• Boiling Point: 294.8°Cat760mmHg
• Flash Point: 132.1°C
• Appearance: /
• Density: 1.138g/cm³
• Vapor Pressure: 0.00159mmHg at 25°C
• Refractive Index: 1.455
• PKA: 16.37±0.40(Predicted)
• CAS DataBase Reference: 4-chlorobutyramide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chlorobutyramide(2455-04-1)
• EPA Substance Registry System: 4-chlorobutyramide(2455-04-1)

Safety Data

• Hazardous Substances Data: 2455-04-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
4-chlorobutyramide is used as a chemical intermediate for the synthesis of various pharmaceuticals and agrochemicals, leveraging its unique chemical structure to facilitate the creation of new and effective compounds.
Used in Organic Synthesis:
4-chlorobutyramide is utilized as a building block in organic synthesis, contributing to the development of drugs and other bioactive molecules, thanks to its reactive chemical properties.
Used as a Corrosion Inhibitor:
4-chlorobutyramide has been studied for its potential use as a corrosion inhibitor, indicating its application in industries where metal protection is crucial to prevent degradation and extend the service life of equipment.
Used as an Additive in Pharmaceutical Formulations:
4-chlorobutyramide is considered for use as an additive in pharmaceutical formulations to enhance the properties of drugs, such as solubility, stability, or bioavailability, thereby improving the overall effectiveness of the medication.

InChI:InChI=1/C4H8ClNO/c5-3-1-2-4(6)7/h1-3H2,(H2,6,7)

Upstream product

• 628-20-6 4-Chlorobutyronitrile 
• 137424-96-5 4-chloro-butyraldehyde-oxime 
• 89224-42-0 ethyl γ-chlorobutyrimidate hydrochloride 
• 3153-36-4 4-chloro-butyric acid ethyl ester 
• 4635-59-0 4-Chlorobutanoyl chloride 

Downstream Products

• 628-20-6 4-Chlorobutyronitrile 
• 4641-57-0 1-phenylpyrrolidin-2-one 
• 1286232-47-0 N-(4-phenylamino)butyramide 
• 1286232-48-1 N-phenyl-4-phenylaminobutyramide 
• 616-45-5 2-pyrrolidinon 

Relevant articles and documents

QUINAZOLINE DERIVATIVE

Provided are a quinazoline derivative, a pharmaceutical composition containing the same, a method for preparation of said derivative, and an application of same as an anti-cancer drug.

NOVEL PYRIDINE DERIVATIVES

The invention relates to a compound of formula (I) wherein R1 to R4 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

PYRIDIN- 2 -AMIDES USEFUL AS CB2 AGONISTS

The invention relates to a compound of formula (I) wherein R1 to R4 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

A facile hydration of nitriles into amides by Al2O3/MeSO3H (AMA)

A new and practical method for the conversion of nitriles to amides by employing the A12O3/MeSO3H (AMA) is described.

4-[diaryl)hydroxymethyl]-1-piperidinealkylcarboxylic acids, salts and esters useful in the treatment of allergic disorders

Novel compounds useful in the treatment of allergic disorders and having the formula: STR1 where Ar and Ar1 are pyridinyl, phenyl, or substituted phenyl and where Y is --OH,--O? M≈ m,--O--loweralkyl, --O--Aryl, or NR1 R2 (R1, R2 =H, loweralkyl, aryl) are herein disclosed.

AN ALTERNATIVE PROCEDURE FOR THE ALUMINUM-MEDIATED CONVERSION OF ESTERS TO AMIDES

A convenient method has been developed for directly converting esters to amides using reagents derived from the reaction of trimethylaluminum with ammonium chloride, methylamine hydrochloride or dimethylamine hydrochloride.

Substituted mercapto acid amides and their use

Substituted mercapto acid amides are prepared, and are useful as immunoregulants for correcting an imbalance of immune homeostasis, particularly as immunostimulants in the treatment of autoimmune and immune deficient diseases and disorders.