24557-17-3Relevant articles and documents
Selective synthesis of dihalo-substituted unsaturated carboxylic acids and derivatives
Langle, Sandrine,Ngi, Samuel Inack,Anselmi, Elsa,Abarbri, Mohamed,Thibonnet, Jerome,Duchene, Alain
, p. 1724 - 1728 (2007)
A selective one-pot procedure was developed for the production of E-dihalo-substituted α,β-unsaturated alkenoic acids and derivatives from the corresponding α,β-unsaturated alkynoic acids. Georg Thieme Verlag Stuttgart.
Carboxylate-directed tandem functionalisations of α,β- dihaloalkenoic acids with 1-alkynes: A straightforward access to (Z)-configured, α,β-substituted γ-alkylidenebutenolides
Inack Ngi, Samuel,Cherry, Khalil,Héran, Virginie,Commeiras, Laurent,Parrain, Jean-Luc,Duchêne, Alain,Abarbri, Mohamed,Thibonnet, Jér?me
supporting information; scheme or table, p. 13692 - 13696 (2012/01/06)
An easy and mild copper(I)-catalysed lactonisation of readily available (E)-2,3-dihalopropenoic acid derivatives regio- and stereoselectively leads to rarely described (Z)-3-halo-5-ylidene-5H-furan-2-ones. These compounds are subsequently able to undergo classical Pd-catalysed cross-coupling reactions, providing 3-substituted and 3,4-disubstituted 5-ylidene-5H-furan-2-ones (see scheme).
