24582-66-9Relevant academic research and scientific papers
Light-Driven Enantioselective Synthesis of Pyrroline Derivatives by a Radical/Polar Cascade Reaction
Rodríguez, Ricardo I.,Mollari, Leonardo,Alemán, José
supporting information, p. 4555 - 4560 (2021/01/18)
Herein, a light-driven, atom-economical process that provides access to enantiomerically enriched substituted chiral 1-pyrroline derivatives is introduced. The strategy involves the distal functionalization of acyl heterocycles through a hydrogen-atom transfer (HAT) process and the use of tailor-made ketimines as reliable electrophilic partners. This transformation is translated into an enantiomerically controlled radical/polar cascade reaction in which water is produced as the sole by-product and stereoselectivity is dictated by coordination to a chiral-at-rhodium catalyst.
Three Step Synthesis of Fully and Differently Arylated Pyridines
Arita, Mao,Yokoyama, Soichi,Asahara, Haruyasu,Nishiwaki, Nagatoshi
, p. 466 - 474 (2020/01/25)
Condensation of β-(2-pyridyl)enamine and α,β-unsaturated ketone in the presence of FeCl3 under air afforded highly substituted pyridines. In this transformation, FeCl3 acted as not only an acid catalyst but also an oxidant for the in
Synthesis, characterization and biological application of pyrazolo[1,5-a]pyrimidine based organometallic Re(I) complexes
Bhatt, Bhupesh S.,Pandya, Juhee G.,Patel, Mohan N.,Pathak, Chandramani,Vaidya, Foram U.,Varma, Reena R.
, p. 957 - 969 (2020/10/02)
The neutral rhenium(I) complexes (I-VI) of type [ReCl(CO)3Ln] {where L1 = 7-phenyl-5-(pyridin-2-yl)pyrazolo[1,5-a] pyrimidine, L2 = 7-(4-bromophenyl)-5-(pyridin-2-yl)pyrazolo[1,5-a]pyrimi- dine, L3 =
Fabrication of Copper-based Silica-coated Magnetic Nanocatalyst for Efficient One-pot Synthesis of Chalcones via A3 Coupling of Aldehydes-Alkynes-Amines
Yadav, Priya,Yadav, Manavi,Gaur, Rashmi,Gupta, Radhika,Arora, Gunjan,Rana, Pooja,Srivastava, Anju,Sharma, Rakesh K.
, p. 2488 - 2496 (2020/03/26)
In the present work, we have synthesized bioactive and pharmacologically important chalcone motifs by employing green and efficient silica-coated magnetically separable catalyst, Cu@DBM@ASMNPs. The highly proficient nanocatalyst proves its invincibility f
Restraining Cancer Cells by Dual Metabolic Inhibition with a Mitochondrion-Targeted Platinum(II) Complex
Wang, Kun,Zhu, Chengcheng,He, Yafeng,Zhang, Zhenqin,Zhou, Wen,Muhammad, Nafees,Guo, Yan,Wang, Xiaoyong,Guo, Zijian
supporting information, p. 4638 - 4643 (2019/03/07)
Cancer cells usually adapt metabolic phenotypes to chemotherapeutics. A defensive strategy against this flexibility is to modulate signaling pathways relevant to cancer bioenergetics. A triphenylphosphonium-modified terpyridine platinum(II) complex (TTP)
Design and development of a heterogeneous catalyst for the michael addition of malononitrile to 2-enoylpyridines: Influence of the primary amide decorated framework on catalytic activity and selectivity
Markad, Datta,Khullar, Sadhika,Mandal, Sanjay K.
supporting information, p. 12547 - 12554 (2019/10/11)
For the Michael addition of malononitrile to 2-enoylpyridines, we report the first heterogeneous catalyst, {[Zn2(2-bpbg)(fum)2]·4H2O·EtOH}n (1) (where 2-bpbg = N,N′-bis(2-pyridylmethyl)-1,4-diaminobutane-N,N′-di
The synthesis and structures of arene-substituted azadipyrromethenes
Chanawanno, Kullapa,Hasheminasab, Abed,Engle, James T.,Ziegler, Christopher J.
, p. 276 - 281 (2015/10/19)
We present the synthesis of several azadipyrromethenes with four peripheral arene units which can be readily generated via the well-established chalcone synthetic method. The stability and yields of these azadipyrromethenes is highly dependent on the nature of the arene substituent, with the bis-pyridine systems exhibiting the highest degree of instability. The structures of several of the compounds and their BF2 adducts are presented; intramolecular hydrogen bonding is observed in the free base ADPMs. We also present a study into the absorption and emission properties of the ADPMs and their BF2 adducts and observe that they are also highly dependent on the identity of the substituents.
Diastereo- and enantioselective direct vinylogous Michael addition of γ-substituted butenolides to 2-enoylpyridines catalyzed by chiral bifunctional amine-squaramides
Wang, Zhen-Hua,Wu, Zhi-Jun,Huang, Xue-Qun,Yue, Deng-Feng,You, Yong,Xu, Xiao-Ying,Zhang, Xiao-Mei,Yuan, Wei-Cheng
supporting information, p. 15835 - 15838 (2015/11/10)
The diastereo- and enantioselective direct vinylogous Michael addition reaction of γ-substituted butenolides to 2-enoylpyridines has been achieved. A range of γ,γ-disubstituted butenolide derivatives, bearing two consecutive tri- and tetrasubstituted stereogenic centers, were readily obtained in good yields with excellent stereoselectivities (up to >99:1 dr and >99% ee).
EGFR/HER-2 inhibitors: Synthesis, biological evaluation and 3D-QSAR analysis of dihydropyridine-containing thiazolinone derivatives
Ren, Yu-Jia,Wang, Zhong-Chang,Zhang, Xin,Qiu, Han-Yue,Wang, Peng-Fei,Gong, Hai-Bin,Jiang, Ai-Qin,Zhu, Hai-Liang
, p. 21445 - 21454 (2015/03/30)
A series of dihydropyridine containing thiazolinone derivatives (4a-4r) have been designed, synthesized and their biological activities evaluated as potential EGFR and HER-2 kinase inhibitors and in tumor cell antiproliferation. The synthesized compounds
