24589-78-4

Basic information

• Product Name: N-Methyl-N-(trimethylsilyl)trifluoroacetamide
• Synonyms: 2,2,2-TRIFLUORO-N-METHYL-N-(TRIMETHYLSILYL)-ACETAMIDE;N-METHYL-N-(TRIMETHYLSILYL)TRIFLUORO;MSTFA MSTFA;2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)acetamide for gas chromatography;N-METHYL-N-TMS-TRIFLUOROACETAMIDE;N-METHYL-N-TRIMETHYLSILYLTRIFLUOROACETAMIDE;N-METHYL-N-TRIMETHYLSILYLTRIFLUOROACETAMIDE ACTIVATED I;N-METHYL-N-TRIMETHYLSILYLTRIFLUOROACETAMIDE ACTIVATED II
• CAS NO: 24589-78-4
• Molecular Formula: C₆H₁₂F₃NOSi
• Molecular Weight: 199.25
• EINECS: 246-331-6
• Product Categories: Analytical Chemistry;GC Derivatizing Reagents;Si (Classes of Silicon Compounds);Silylacetamides;Silylation (GC Derivatizing Reagents);Si-N Compounds;Trimethylsilylation (GC Derivatizing Reagents);Reagents for SilylationProtection and Derivatization;Silicon-BasedAnalytical/Chromatography;Protecting and Derivatizing Reagents;Silylation Reagents;Derivatization Reagents;Derivatization Reagents GC;Reagents for SilylationAnalytical/Chromatography;Amines;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Silylation Reagents;Amines, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 24589-78-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 98-100°C
• Boiling Point: 130132°C
• Flash Point: 77 °F
• Appearance: Clear colorless to light yellow/Liquid
• Density: 1.075 g/mL at 25 °C(lit.)
• Vapor Density: >1 (vs air)
• Vapor Pressure: 8.8 mm Hg ( 27 °C)
• Refractive Index: n20/D 1.383
• Storage Temp.: 2-8°C
• PKA: -1.34±0.70(Predicted)
• Water Solubility: reacts
• Sensitive: Moisture Sensitive
• BRN: 1941550
• CAS DataBase Reference: N-Methyl-N-(trimethylsilyl)trifluoroacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Methyl-N-(trimethylsilyl)trifluoroacetamide(24589-78-4)
• EPA Substance Registry System: N-Methyl-N-(trimethylsilyl)trifluoroacetamide(24589-78-4)

Safety Data

• Hazard Codes: Xi,F,T,N
• Statements: 10-36/37/38-61-50/53-51/53
• Safety Statements: 26-36-37/39-16-45-53-61
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• RTECS: AC9800000
• F: 10-21
• TSCA: T
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 24589-78-4(Hazardous Substances Data)

Usage

Chemical Properties

Clear colorless to light yellow liquid

Uses

Different sources of media describe the Uses of 24589-78-4 differently. You can refer to the following data:
1. A new metabolite of Famprofazone in humans.
2. pharmaceutical intermediate
3. N-Methyl-N-(trimethylsilyl)trifluoroacetamide is used as a silylating reagent that forms volatile derivatives for GC-MS analysis. It acts as a pharmaceutical intermediate and metabolite of Famprofazone in humans. It is also used in the detection of steroid hormones 17-alfa-ethynylestradiol and estrone.

Definition

ChEBI: An N-silyl compound that is N-methyltrifluoroacetamide in which the amide nitrogen is replaced by a trimethylsilyl group. N-methyl-N-(trimethylsilyl)trifluoroacetamide is a derivat sation agent used in gas chromatography/mass spectrometry applications.

General Description

N-Methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA) is a derivatizing reagent. It can be used as alternatives to diazomethane.

Purification Methods

Fractionate the amide through a 40mm Vigreux column (p 11). Usually it contains ca 1% of methyl trifluoroacetamide and 1% of other impurities which can be removed by gas chromatography or fractionating using a spinning band column. [Donike J Chromatogr 42 103 1969, Donike J Chromatogr 103 91 1975, Beilstein 4 IV 4011.]

InChI:InChI=1/C6H12F3NOSi/c1-10(12(2,3)4)5(11)6(7,8)9/h1-4H3

Upstream product

• 10416-59-8 N,O-bis-(trimethylsilyl)-acetamide 
• 815-06-5 N-methyl-2,2,2-trifluoroacetamide 

Downstream Products

• 55887-55-3 N,O-Bis(trimethylsilyl)-5-methoxyindolyl-3-essigsaeureester 
• 96657-86-2 2,2,2-Trifluoro-N-methyl-N-(phenyl-trimethylsilanyloxy-methyl)-acetamide 
• 815-06-5 N-methyl-2,2,2-trifluoroacetamide 
• 18107-22-7 N,N-Bis(trimethylsilyl)pentylamine 
• 62269-44-7 methyl 3-trimethylsiloxybut-2-enoate 
• 60068-18-0 1-Trimethylsilanyloxy-4-(1-trimethylsilanyloxy-vinyl)-benzene 
• 25495-26-5 3,17β-Bis<(trimethylsilyl)oxy>-3,5-androstadiene 
• 959-21-7 3,6-dipentyl-[1,4]dioxane-2,5-diol 
• 51048-29-4 1,2-ethanedithiobis(trimethylsilane) 
• 18132-77-9 1,3-bis(trimethylsilyl)tetrahydropyrimidin-2-one 

Relevant articles and documents

Method of Synthesizing of N-methyl-N-trimethylsilyl trifluoroacetamide, N-methyl-N-trimethylsilyl trifluoroacetamide synthesized thereby and an electrolyte for lithium secondary battery including the same

The present invention relates to a synthesis method of N-methyl-N-trimethylsilyl trifluoroacetamide (MSTFA), MSTFA synthesized thereby and an electrolyte for a lithium secondary battery including the same. The present invention comprises the steps of: preparing N-methyltrifluoroacetamide by using ethyltrifluoroacetate and methylamine; and obtaining MSTFA by separating and removing a precipitate from a reaction mixture obtained by introducing trimethylsilyl chloride to a mixture of N-methyltrifluoroacetamide and triethylamine. According to the present invention, since BSA (N,O-bis(trimethylsilyl)acetamide) is not used, it is relatively easy to remove a starting material and a side reaction material which are not reacted by fractional distillation. Therefore, it is possible to obtain a high-purity MSTFA of 99.0% or more and if the high-purity MSTFA of 99.0% or more is used as an additive of an electrolyte for a lithium secondary battery, it is possible to improve lifespan characteristics of a lithium secondary battery.COPYRIGHT KIPO 2015

Bis-trimethylsilyl cefamandole and process therefor

Bis-trimethylsilyl cefamandole is useful for regenerating cefamandole of excellent purity.