18401-58-6

Basic information

• Product Name: 1-Trimethylsiloxy-4-trimethylsiloxymethylbenzene
• Synonyms: 1-Trimethylsiloxy-4-trimethylsiloxymethylbenzene;Trimethyl[[p-[(trimethylsilyl)oxy]benzyl]oxy]silane
• CAS NO: 18401-58-6
• Molecular Formula: C₁₃H₂₄O₂Si₂
• Molecular Weight: 0
• Mol File: 18401-58-6.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Trimethylsiloxy-4-trimethylsiloxymethylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Trimethylsiloxy-4-trimethylsiloxymethylbenzene(18401-58-6)
• EPA Substance Registry System: 1-Trimethylsiloxy-4-trimethylsiloxymethylbenzene(18401-58-6)

Safety Data

• Hazardous Substances Data: 18401-58-6(Hazardous Substances Data)

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 623-05-2 (4-hydroxyphenyl)methanol 
• 99-96-7 4-hydroxy-benzoic acid 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 
• 25561-30-2 N,O-bis(trimethylsilyl)trifluoroacetamide 
• 24589-78-4 N-methyl-N-trimethylsilyl-2,2,2-trifluoroacetamide 
• 108-95-2 phenol 

Downstream Products

• 207679-81-0 (R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)-phenol 
• 200801-70-3 RS-N,N-diisopropyl-3-(2-hydroxy-5-(hydroxymethyl)phenyl)-3-phenylpropylamine 
• 959624-24-9 (2-hydroxy-4-phenyl-3,4-dihydro-2H-chromen-6-yl)methanol 
• 623-05-2 (4-hydroxyphenyl)methanol 
• 115255-87-3 4-trimethylsilyloxymethylphenol 
• 115255-86-2 (4-Trimethylsilanyloxy-phenyl)-methanol 

Relevant articles and documents

A simple and efficient room temperature silylation of diverse functional groups with hexamethyldisilazane using CeO2 nanoparticles as solid catalysts

In this study, a mild and efficient method is developed for the silylation of diverse functional groups using CeO2 nanoparticles (n-CeO2) as solid catalysts with hexamethyldisilazane (HMDS) as silylating agent at room temperature. Alcohols, phenols and acids are silylated to their respective silyl derivatives with faster reaction rate while amines and thiols required relatively longer reaction time. Moreover, the solid catalyst is easily be separated from the reaction mixture and recycled more than five times without any obvious decay in its activity. Powder X-ray diffraction (XRD), transmission electron microscope (TEM), UV–vis diffuse reflectance spectra (UV-DRS) and Raman analyses revealed identical structural integrity, particle size, absorption edge and valence state for the reused solid compared to the fresh solid catalyst.

Rapid and efficient trimethylsilyl protection of hydroxyl groups catalyzed by niobium(V) chloride

An efficient and convenient procedure for the trimethylsilylation of a wide variety of alcohols, including primary, benzylic, secondary, and phenols with hexamethyldisilazane, has been developed. The reactions were carried out at room temperature in the presence of a catalytic amount of niobium(V) chloride and afforded the corresponding trimethylsilyl ethers in high to excellent yields in short time. Copyright Taylor & Francis Group, LLC.

Heterogeneous catalysis in trimethylsilylation of alcohols and phenols by zirconium sulfophenyl phosphonate

Layered zirconium sulfophenyl phosphonate was found to be an efficient heterogeneous catalyst for the trimethylsilylation of alcohols and phenols.