24622-62-6

Basic information

• Product Name: 1-(3',4'-Methylenedioxyphenyl)-2-pyrrolidino-1-pentanone hydrochloride
• Synonyms: 1-(3',4'-Methylenedioxyphenyl)-2-pyrrolidino-1-pentanonehydrochloride;1-(1,3-Benzodioxol-5-yl)-2-(1-pyrrolidinyl)-1-pentanone hydrochloride;1-(3,4-METHYLENEDIOXY-PHENYL)-2-PYRROLIDINO-1-PENTANONE HYDROCHLORIDE (VALEROPHENONE);MDPV/MDPK;1-(1,3-Benzodioxol-5-yl)-2-(1-pyrrolidinyl)-1-pentanone HCL;Methylenedioxypyrovalerone Hydrochloride;1-Pentanone, 1-(1,3-benzodioxol-5-yl)-2-(1-pyrrolidinyl)-, hydrochloride (1:1);1-(3,4-methylenedioxyphenyl)-2-pyrrolidinyl-pentan-1-one HCI
• CAS NO: 24622-62-6
• Molecular Formula: C16H21NO3.HCl
• Molecular Weight: 311.81
• Product Categories: Amines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Research Chemical;Chemical for Research;pharmaceutical intermediates;Medical research
• Mol File: 24622-62-6.mol
• Article Data: 2

Chemical Properties

• Melting Point: 229-234°C
• Boiling Point: 415.5 °C at 760 mmHg
• Flash Point: 9℃
• Appearance: /
• Density: 0.951 g/cm³
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• CAS DataBase Reference: 1-(3',4'-Methylenedioxyphenyl)-2-pyrrolidino-1-pentanone hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3',4'-Methylenedioxyphenyl)-2-pyrrolidino-1-pentanone hydrochloride(24622-62-6)
• EPA Substance Registry System: 1-(3',4'-Methylenedioxyphenyl)-2-pyrrolidino-1-pentanone hydrochloride(24622-62-6)

Safety Data

• Hazard Codes: Xi,N,T,F
• Statements: 41-50-39/23/24/25-23/24/25-11
• Safety Statements: 26-39-61-45-36/37-16
• RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
• WGK Germany: 1
• Hazardous Substances Data: 24622-62-6(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Methylenedioxy pyrovalerone (MDPV) is a central nervous system

Upstream product

• 616-45-5 2-pyrrolidinon 
• 146721-06-4 (+/-)-(1R*)-1-Bromo-1-(3,4-methylenedioxybenzoyl)butane 
• 274-09-9 Methylenedioxybenzene 
• 638-29-9 n-valeryl chloride 
• 687603-66-3 MDPV 

Downstream Products

• 687603-66-3 MDPV 

Relevant articles and documents

Is the 3,4-methylendioxypyrovalerone/mephedrone combination responsible for enhanced stimulant effects? A rat study with investigation of the effect/concentration relationships

Rationale: The use of synthetic cathinones as recreational drugs frequently sold in combination has been increasing exponentially. However, the consequences of combining cathinones on the resulting stimulant effects and the pharmacokinetics have been poorly investigated. Objective and methods: To study 3,4-methylenedioxypyrovalerone (MDPV; 3?mg/kg) and mephedrone (4-MMC; 30?mg/kg)-induced effects on rat locomotor activity and pharmacokinetics, administered alone or in combination by the intragastric route. The pharmacokinetic parameters were determined using non-compartmental analysis and the relationships between the locomotor activity and drug concentrations using sigmoidal Emax modeling. Results: Locomotor activity significantly increased during the first hour post-administration with the MDPV/4-MMC combination in comparison to MDPV (p max (16.4 ± 5.5 versus 62.2 ± 14.2?μg/L, p 0 → ∞ (708 ± 91 versus 3316 ± 682?μg/L/min, p max model fitted the observed data well; MDPV being markedly more potent than 4-MMC (EC50, 0.043 versus 0.7?μmol/L). The enhancing factor representing the MDPV contribution to the alteration in the relationships between locomotor activity and 4-MMC concentrations was 0.3. Conclusion: An MDPV/4-MMC combination results in enhanced stimulant effects in the rat, despite significant reduction in MDPV bioavailability. Enhanced effects could be explained by increased MDPV distribution and/or possible complementation at the brain dopaminergic targets. However, the exact consequences of the MDPV/4-MMC combination in humans remain to be clarified.