246244-10-0Relevant articles and documents
Novel homoisoflavanone derivatives, preparation method thereof, and pharmaceutical composition for use in preventing or treating ischemic brain damage and multiple sclerosis containing the same as an active ingredient
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, (2018/07/14)
The present invention relates to: a homoisoflavanone compound; a manufacturing method thereof; and a pharmaceutical composition for preventing or treating ischemic brain damage and multiple sclerosis containing the homoisoflavanone compound as an active i
Organocatalyzed enantioselective protonation of silyl enol ethers: Scope, limitations, and application to the preparation of enantioenriched homoisoflavones
Poisson, Thomas,Gembus, Vincent,Dalla, Vincent,Oudeyer, Sylvain,Levacher, Vincent
experimental part, p. 7704 - 7716 (2010/12/29)
In the present work, enantioselective protonation of silyl enol ethers is reported by means of a variety of chiral nitrogen bases as catalysts, mainly derived from cinchona alkaloids, in the presence of various protic nucleophiles as proton source. A detailed study of the most relevant reaction parameters is disclosed allowing high enantioselectivities of up to 92% ee with excellent yields to be achieved under mild and eco-friendly conditions. The synthetic utility of this organocatalytic protonation was demonstrated during the preparation of two homoisoflavones 4a and 4b, isolated from Chlorophytum Inornatum and Scilla Nervosa, which were obtained with 81% and 78% ee, respectively.
New convenient synthesis of homoisoflavanones and (±)-di-O- methyldihydroeucomin
Kirkiacharian, B. Serge,Gomis, Michel
, p. 563 - 569 (2007/10/03)
Upon reaction of 1-(2-hydroxyphenyl)-3-phenylpropane-1-ones (2′-hydroxydihydrochalcones) with dimethylaminodimethoxymethane in boiling toluene, the corresponding 3-benzylchromones are obtained in excellent yields. These latter lead to 3-benzylchroman-4-on
An improved synthesis of homoisoflavanones
Jaspal, Sharda,Grover
, p. 1782 - 1783 (2007/10/03)
2′-Hydroxydihydrochalcones i.e. 1-(2-hydroxyphenyl)-3- phenylpropanones having different oxygenation patterns in ring-A and ring-B, on refluxing with paraformaldehyde powder and aqueous diethylamine in ethanol give the corresponding homoisoflavanones in excellent yields.
A highly enantioselective synthesis of (R)- and (S)-5,7-odimethyleucomol
Davis, Franklin A.,Chen, Bang-Chi
, p. 6823 - 6826 (2007/10/02)
Both (R)- and (S)-5,7-O-dimethyleucomol 1b (R = Me) were synthesized in 57% overall yield in>96% enantiomeric excess. The key step involves the enantioselective α hydroxylation of the lithium enolate of 8 by readily available (+)- and (-)-[(8,8-dimethoxyc
Phase Transfer Catalysed Hydroxymethylation of 2'-Hydroxydihydrochalcones: A New Synthesis of Homoisoflavanones
Pinkey,Jain, P. K.,Grover, S. K.
, p. 365 - 367 (2007/10/02)
2'-Hydroxydihydrochalcones having different oxygenation patterns in rings A and B, on treatment with formalin in chloroform-saturated aqueous potassium carbonate biphase system in the presence of a phase transfer catalyst (tetra-n-butylammonium hydrogen s
A New Biogenetic Approach for the Synthesis of Homoisoflavanones
Makrandi, J. K.,Grover, S. K.
, p. 739 - 743 (2007/10/02)
2'-Hydroxydihydrochalkones on refluxing with methylene iodide in acetone medium in the presence of anhydrous potassium carbonate have been found to yield bi(dihydrochalkonyloxy)methanes and homoisoflavanones.