34811-77-3

Upstream product

• 3791-75-1 2'-hydroxy-4,4',6'-trimethoxydihydrochalcone 
• 109-94-4 formic acid ethyl ester 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 1188-33-6 N,N-dimethylformamide diethyl diacetal 
• 124-63-0 methanesulfonyl chloride 
• 123-11-5 4-methoxy-benzaldehyde 
• 3420-72-2 flavokawain A 
• 90-24-4 2-hydroxy-4,6-dimethoxyacetophenone 
• 3420-72-2 2'-hydroxy-4,4',6'-trimethoxychalcone 
• 27181-65-3 5,7-dimethoxy-3-(4'-methoxybenzylidene)chroman-4-one 

Downstream Products

• 246244-10-0 rac-5,7-dimethoxy-3-(4-methoxybenzyl)-chroman-4-one 
• 17934-14-4 (S)-5,7-dimethoxy-3-(4-methoxybenzyl)chroman-4-one 

Relevant academic research and scientific papers

New homoisoflavonoid analogues protect cells by regulating autophagy

As a special group of naturally occurring flavonoids, homoisoflavonoids have been discovered as active components of several traditional Chinese medicines for nourishing heart and mind. In this study, twenty homoisoflavonoid analogues, including different substitution groups on rings A and B, as well as heteroaromatic B ring, were synthesized and evaluated for their cardioprotective and neuroprotective activities. In a H2O2-induced H9c2 cardiomyocytes injury assay, nine homoisoflavonoid analogues showed promising activities in the same level as the positive control, diazoxide. Six cardioprotective compounds with representative structure diversities were then evaluated for their neuroprotective effects on MPP+ induced SH-SY5Y cell injury model. Furthermore, autophagy inducing monodansylcadaverine (MDC) fluorescence staining methods and molecular docking studies indicated the action mechanism of these compounds may involve autophagy regulating via class I PI3K signaling pathway.

Organocatalyzed enantioselective protonation of silyl enol ethers: Scope, limitations, and application to the preparation of enantioenriched homoisoflavones

In the present work, enantioselective protonation of silyl enol ethers is reported by means of a variety of chiral nitrogen bases as catalysts, mainly derived from cinchona alkaloids, in the presence of various protic nucleophiles as proton source. A detailed study of the most relevant reaction parameters is disclosed allowing high enantioselectivities of up to 92% ee with excellent yields to be achieved under mild and eco-friendly conditions. The synthetic utility of this organocatalytic protonation was demonstrated during the preparation of two homoisoflavones 4a and 4b, isolated from Chlorophytum Inornatum and Scilla Nervosa, which were obtained with 81% and 78% ee, respectively.

New convenient synthesis of homoisoflavanones and (±)-di-O- methyldihydroeucomin

Upon reaction of 1-(2-hydroxyphenyl)-3-phenylpropane-1-ones (2′-hydroxydihydrochalcones) with dimethylaminodimethoxymethane in boiling toluene, the corresponding 3-benzylchromones are obtained in excellent yields. These latter lead to 3-benzylchroman-4-on

A highly enantioselective synthesis of (R)- and (S)-5,7-odimethyleucomol

Both (R)- and (S)-5,7-O-dimethyleucomol 1b (R = Me) were synthesized in 57% overall yield in>96% enantiomeric excess. The key step involves the enantioselective α hydroxylation of the lithium enolate of 8 by readily available (+)- and (-)-[(8,8-dimethoxyc

Synthesis and angioprotective, antiallergic and antihistaminic activities of 3-benzyl-chromones (homoisoflavones)

Various 3-benzyl-chromones were prepared and their angioprotective antiallergic and antihistaminic activities were studied. - 3-benzyl-chromones / antiallergic / antihistaminic / angioprotective

Isomerisation of 3-Benzylidene-4-chromanones in Presence of Alkali

3-Benzylidene-4-chromanones (Ia-d) having 7-methoxy, 7-benzyloxy- or 5,7-dimethoxy groupings in ring-A undergo alkali isomerisation to yield both the corresponding 3-benzyl-4-chromones (IIa-d) and 3-methylflavones (IIIa-d).Hence both the types of isomeris