246529-82-8

Basic information

• Product Name: 3-(o-Methoxyphenyl)-2-methylpropionaldehyde
• Synonyms: 3-(o-Methoxyphenyl)-2-methylpropionaldehyde
• CAS NO: 246529-82-8
• Molecular Weight: 178.231
• Mol File: 246529-82-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-(o-Methoxyphenyl)-2-methylpropionaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(o-Methoxyphenyl)-2-methylpropionaldehyde(246529-82-8)
• EPA Substance Registry System: 3-(o-Methoxyphenyl)-2-methylpropionaldehyde(246529-82-8)

Safety Data

• Hazardous Substances Data: 246529-82-8(Hazardous Substances Data)

Upstream product

• 120958-26-1 (E)-3-(2-methoxyphenyl)-2-methylacrylaldehyde 
• 5720-06-9 2-Methoxyphenylboronic acid 
• 3698-28-0 2-allylanisole 
• 64-18-6 formic acid 
• 135-02-4 ortho-anisaldehyde 
• 78-85-3 2-methylpropenal 
• 100-66-3 methoxybenzene 
• 64-17-5 ethanol 

Downstream Products

• 52427-12-0 rac-3-(2-methoxyphenyl)-2-methylpropanoic acid 
• 264258-78-8 (R)-3-(o-Methoxyphenyl)-2-methylpropan-1-ol 
• 120958-24-9 3-(o-Methoxyphenyl)-2-methylpropan-1-ol 

Relevant articles and documents

Carbonylative Transformation of Allylarenes with CO Surrogates: Tunable Synthesis of 4-Arylbutanoic Acids, 2-Arylbutanoic Acids, and 4-Arylbutanals

In this Communication, procedures for the selective synthesis of 4-arylbutanoic acids, 2-arylbutanoic acids, and 4-arylbutanals from the same allylbenzenes have been developed. With formic acid or TFBen as the CO surrogate, reactions proceed selectively and effectively under carbon monoxide gas-free conditions.

Diastereoselective addition of methylmetal reagents to 2-methylaldehydes

The preparation of compounds incorporating the 3-hydroxy-2-methyl-1-butyl moiety of high diastereomeric purity is described. These compounds can serve as potential building blocks for the preparation of several kinds of natural products. The diastereoselective addition of a number of methylmetal derivatives to three 3-substituted 2-methylaldehydes in various solvents was studied. An excellent diastereomeric ratio (95:5 anti-Cram/Cram) was obtained with 2-methyl-3-(phenylsulfanyl)propanal (5) and Me2Zn in the presence of TiCl4.