24654-07-7

Upstream product

• 3752-25-8 o-chlorocinnamic acid 
• 704-96-1 trans-2-chlorocinnamic acid 
• 7726-95-6 bromine 
• 64-19-7 acetic acid 
• 704-96-1 (Z)-3-(2-chlorophenyl)acrylic acid 
• 89-98-5 2-chloro-benzaldehyde 

Downstream Products

• 880142-94-9 α-bromo-2-chloro-cis-cinnamic acid 
• 3752-25-8 o-chlorocinnamic acid 
• 76557-95-4 (Z)-1-(2-bromovinyl)-3-chlorobenzene 
• 187463-09-8 (Z)-1-(2-bromovinyl)-2-chlorobenzene 
• 333309-74-3 (E)-1-(2'-chlorophenyl)-2-bromoethylene 
• 1345842-04-7 4-(2-chlorophenyl)-1-(4-methylphenyl)-1,2,3-triazole 
• 873-31-4 2-chlorophenylacetylene 
• 1607020-78-9 N-(4-methylphenyl)-3-exo-(2-chlorobenzylidene)tricyclo[3.2.1.02,4]octane-6,7-endo-dicarboximide 

Relevant academic research and scientific papers

Palladium(0)-Catalyzed Methylcyclopropanation of Norbornenes with Vinyl Bromides and Mechanism Study

An unusual methylcyclopropanation from [2 + 1] cycloadditions of vinyl bromides to norbornenes catalyzed by Pd(OAc)2/PPh3 in the presence of CH3ONa and CH3OH has been established. A methylcyclopropane subunit was installed by a 3-fold domino procedure involving a key protonation course. Preliminary deuterium-labeling studies revealed that the proton came from methyl of CH3OH and also exposed an additional hydrogen/deuterium exchange process. These two proton-concerned reactions were fully chemoselective.

Palladium(0)-catalyzed methylenecyclopropanation of norbornenes with vinyl bromides

Highly strained methylenecyclopropane derivatives have been achieved via a novel and efficient Pd(0)-catalyzed domino reaction. The formal [2 + 1] cycloaddition reaction of vinyl bromides to norbornenes involves a Heck-type coupling and a C(sp2)-H bond activation.

Convenient synthesis of terminal alkynes from anti-3-aryl-2,3- dibromopropanoic acids using a K2CO3/DMSO system

A convenient, efficient, and generally applicable method was developed for the synthesis of terminal alkynes from anti-3-aryl-2,3-dibromopropanoic acids in the presence of DMSO and K2CO3.

Synthesis of (Z)-1-bromo-1-alkenes and terminal alkynes from anti-2,3-dibromoalkanoic acids by microwave-induced reaction

(Z)-1-Bromo-1-alkenes were stereoselectively prepared in high yields in a short reaction time by microwave irradiation of the corresponding anti-2,3-dibromoalkanoic acids in a Et3N/DMF system. A one-pot synthesis of terminal alkynes and enynes from 2,3-dibromoalkanoic acids were also developed by microwave-induced reaction.

Convenient and stereoselective synthesis of (Z)-1-bromo-1-alkenes by microwave-induced reaction

(Z)-1-Bromo-1-alkenes were stereoselectively prepared in high yields in a short reaction time (0.2-1.0 min) by microwave irradiation of the corresponding 2,3-dibromoalkanoic acids in DMF in the presence of triethylamine.

Polycyclic thiazolidin-2-ylidene amines, process for their preparation, and their use as pharmaceuticals

Polycyclic thiazolidin-2-ylidene amines and their physiologically tolerable salts and physiologically functional derivatives of the formula I in which the radicals have the meanings indicated, and their physiologically tolerable salts and a process for their preparation are described. The compounds are suitable, for example, as anorectics.

Iodide-induced Debromination of Cinnamic Acid and Substituted Cinnamic Acid Dibromides in 2-Methoxyethanol

The second order rate constants for the iodide-induced debromination of cinnamic acid and substituted cinnamic acid dibromides in 2-methoxyethanol are reported; the reactivities follow the order: p-OCH3 > o-CH3 > p-CH3 > p-NO2 > p-Cl > m-NO2 > -H > m-CH3 > m-OCH3 > o-Cl.The m-CH3 and p-Cl derivatives have higher enthalpies and lower negative entropies of activation whereas methoxy substituted derivatives are characterised by lower enthalpies and higher negative entropies of activation than the unsubstituted acid.The free energy of activation is nearly constant.