24660-99-9

Upstream product

• 463-71-8 thiophosgene 
• 4734-09-2 1-[4-(2-methylpropyloxy)phenyl]methanamine 
• 333-20-0 potassium thioacyanate 
• 40141-14-8 4-isobutoxybenzyl chloride 

Downstream Products

• 706779-91-1 N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide 

Relevant academic research and scientific papers

Novel and environmentally friendly synthesis of pimavanserin (5-HT2A receptor)

Eco-friendly synthesis of pimavanserin was developed from the key starting material 4-isobutoxy benzylamine in three different routes using water as solvent. These reactions provide an advantage of easy workup, good yields of products and uses water as the solvent. No column purification was required for the isolation of the product.