Novel and environmentally friendly synthesis of pimavanserin (5-HT2A receptor)

Article abstract of DOI:10.14233/ajchem.2019.21808

Eco-friendly synthesis of pimavanserin was developed from the key starting material 4-isobutoxy benzylamine in three different routes using water as solvent. These reactions provide an advantage of easy workup, good yields of products and uses water as the solvent. No column purification was required for the isolation of the product.