84863-77-4

Basic information

• Product Name: 2-Thiopheneacetic acid, 5-(4-chlorophenyl)-, methyl ester
• CAS NO: 84863-77-4
• Molecular Formula: C13H11ClO2S
• Molecular Weight: 266.748
• Mol File: 84863-77-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-Thiopheneacetic acid, 5-(4-chlorophenyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiopheneacetic acid, 5-(4-chlorophenyl)-, methyl ester(84863-77-4)
• EPA Substance Registry System: 2-Thiopheneacetic acid, 5-(4-chlorophenyl)-, methyl ester(84863-77-4)

Safety Data

• Hazardous Substances Data: 84863-77-4(Hazardous Substances Data)

Upstream product

• 649569-56-2 methyl 5-(4-chlorophenyl)thiophene-2-carboxylate 
• 24680-31-7 2-(5-(4-chlorophenyl)thiophen-2-yl)acetonitrile 
• 108-90-7 chlorobenzene 
• 40133-23-1 2-(4-chlorophenyl)thiophene 
• 24680-29-3 [5-(4-chloro-phenyl)-thiophen-2-yl]-methanol 
• 24680-30-6 2-Chloromethyl-5-(4-chloro-phenyl)-thiophene 
• 67-56-1 methanol 
• 24680-42-0 2-(5-(4-chlorophenyl)thiophen-2-yl)acetic acid 
• 51335-90-1 1-[5-(4-chlorophenyl)thiophen-2-yl]ethan-1-one 

Downstream Products

• 84864-14-2 4-[5-(4-chlorophenyl)-2-thienyl]-3-hydroxy-3-pyrroline-2,5-dione 
• 24675-44-3 2-[5-(4-Chloro-phenyl)-thiophen-2-yl]-acetamide 

Relevant articles and documents

Synthesis and structure-activity relationships of 5-phenylthiophenecarboxylic acid derivatives as antirheumatic agents

5-(Phenylthiophene)-3-carboxylic acid (2a), a metabolite of esonarimod (1), which was developed as a new antirheumatic drug, was considered as a lead compound for new antirheumatic drugs. A new series of 2a derivatives were synthesized and their characteristic pharmacological effects, that is their antagonistic effect toward interleukin (IL)-1 in mice and the suppressive effect against adjuvant-induced arthritis (AIA) in rats, were evaluated and compared with those of 1. The structure-activity relationships indicated that [5-(4-bromophenyl)-thiophen-3-yl]acetic acid (5d), methyl [5-(4-chlorophenyl)-thiophen-3-yl]acetate (5h), and methyl [5-(4-bromophenyl)-thiophen-3-yl]acetate (5i) suppressed AIA more potently than 1 and all of the other synthesized compounds.