24716-94-7

Usage

Uses

Used in Pharmaceutical Industry:
(1S,2S)-2-amino cyclohexane carboxylic acid ethyl ester is used as a pharmaceutical intermediate for the production of various drugs, particularly anti-inflammatory and anti-cancer medications. Its unique structure and properties make it a valuable component in the synthesis of these therapeutic agents.
Used in Laboratory Research:
(1S,2S)-2-amino cyclohexane carboxylic acid ethyl ester is used as a building block for the synthesis of various organic compounds in laboratory research. Its solubility in organic solvents and its reactivity in chemical reactions make it a versatile compound for creating new molecules and studying their properties.
Used in Chemical Synthesis:
(1S,2S)-2-amino cyclohexane carboxylic acid ethyl ester is used as a key component in the synthesis of a wide range of organic compounds. Its ability to participate in various chemical reactions allows for the creation of diverse molecules with potential applications in various industries.

Upstream product

• 1436-60-8 ethyl trans-2-amino-1-cyclohexanecarboxylate 
• 1128-00-3 ethyl 2-aminocyclohex-1-ene-1-carboxylate 
• 1655-07-8 ethyl 2-oxocyclohexane carboxylate 
• 1469-49-4 6-carbamoylcyclohex-3-enecarboxylic acid 
• 64-17-5 ethanol 
• 6294-84-4 cis-1-carboxy-2-(aminocarboxyl)-2-cyclohexane 
• 16524-13-3 (+/-)-N-benzoyl-trans-2-aminocyclohexane-carboxylic acid 
• 29586-50-3 (+)-(S,S)-N-benzoyl-trans-2-aminocyclohexanecarboxylic acid 

Downstream Products

• 213993-31-8 (1S,2S)-2-amino-cyclohexylmethanol 
• 5691-19-0 rac-trans-2-aminocyclohexanecarboxylic acid 
• 92329-81-2 (+/-)-cis-2-(2-ethoxycarbonyl-ethylamino)-cyclohexane-carboxylic acid-⁽¹⁾-ethyl ester 
• 192047-04-4 (1R,2S)-2-aminocyclohexanecarboxylic acid ethyl ester 
• 24716-89-0 cis-2-amino-1-aminomethylcyclohexane 
• 24716-87-8 cis-decahydroquinazoline 
• 29586-59-2 trans-2-hydroxymethylcyclohexylamine 
• 114798-82-2 methyl 2-n-butyl-4-chloro-1-<<4-<2-(trifluoromethanesulfonamido)cyclohexanecarboxamido>phenyl>methyl>imidazole-5-acetate 
• 114772-22-4 trans-2-(trifluoromethanesulfonamido)cyclohexanecarboxylic acid 
• 114772-24-6 (1R,2R)-2-Trifluoromethanesulfonylamino-cyclohexanecarbonyl chloride 
• 114745-56-1 {2-[((1S,2S)-2-Heptanoylamino-cyclohexanecarbonyl)-amino]-acetylamino}-acetic acid ethyl ester 
• 114950-65-1 (r-4a,t-2,c-8a)-3-methyl-2-p-nitrobenzylideneperhydroquinazoline-4-one 
• 114950-65-1 (r-4a,c-2,c-8a)-3-methyl-2-p-nitrobenzylideneperhydroquinazoline-4-one 
• 114950-65-1 (r-4a,t-2,t-8a)-3-methyl-2-p-nitrophenylperhydroquinazolin-4-one 

Relevant academic research and scientific papers

Synthesis of oxazolidin-2-ones and imidazolidin-2-ones directly from 1,3-diols or 3-amino alcohols using iodobenzene dichloride and sodium azide

A general and efficient method for the synthesis of oxazolidin-2-ones and imidazolidin-2-ones directly from 1,3-diols and 3-amino alcohols has been developed using the same reagent combination of iodobenzene dichloride (PhICl2) and sodium azide (NaN3).

Regio- and stereoselective reactions between cyclic Baylis-Hillman type adducts and N-nucleophiles and P-nucleophile

New important organic compounds multifunctionalized cyclic 6-membered and 7-membered allylic amines, azide and phosphonates have been obtained via regio- and diastereoselective reactions of cyclic Baylis-Hillman type adducts 1 with N-nucleophiles and P-nu

Approach to highly enantiopure β-amino acid esters by using lipase catalysis in organic media

Ethyl esters of ten alicyclic β-aminocarboxylic acids were resolved by lipase catalysis in organic solvents. The resolution was based on acylation of the amino group at the R-stereogenic centre with various 2,2,2- trifluoroethyl esters. An increase in the hydrophobic nature of the acyl donor enhanced the enantioselectivity and reactivity in the case of lipase SP 526 from Candida antarctica, while the opposite effect was observed with lipase PS from Pseudomonas cepacia. An unexceptional enantioselectivity enhancement was observed when 2,2,2-trifluoroethyl chloroacetate was used in the case of lipase PS catalysis.

EXPERIMENTAL STUDIES OF THE ANOMERIC EFFECT. PART 2 RING INVERSION AND NITROGEN INVERSION EQUILIBRIA IN CIS-DECAHYDROQUINAZOLINES

The positions of conformational equilibria due to the double ring inversion in cis-decahydroquinazoline (7-->//07-->8 1.08 kcal mol-1; -ΔG09-->10 1.10 kcal mol-1) for the conformation which would allow the lone pairs on N(1) and N(3) to lie on the hindered 'inside' face of the molecules.However, the values of 3J(CHNH) coupling constants for both cis-decahydro-3-methylquinazoline (10) and cis (4aH, 8aH) cis (2H, 8aH)-decahydro-2,3-dimethylquinazoline (14) show that the N-inversion equilibrium at N(1) prefers the conformation in which N(1)-H is 'inside' (axial), and N(1)-lone pair equatorial, thus demonstrating the ability of the anomeric effect to outweigh steric repulsions.