24716-94-7

Basic information

• Product Name: (1S,2S)-2-aMinocyclohexanecarboxylic acid ethyl ester
• Synonyms: (1S,2S)-2-aMinocyclohexanecarboxylic acid ethyl ester
• CAS NO: 24716-94-7
• Molecular Formula: C₉H₁₇NO₂
• Molecular Weight: 171.23678
• Mol File: 24716-94-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (1S,2S)-2-aMinocyclohexanecarboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2S)-2-aMinocyclohexanecarboxylic acid ethyl ester(24716-94-7)
• EPA Substance Registry System: (1S,2S)-2-aMinocyclohexanecarboxylic acid ethyl ester(24716-94-7)

Safety Data

• Hazardous Substances Data: 24716-94-7(Hazardous Substances Data)

Usage

General Description

(1S,2S)-2-amino cyclohexane carboxylic acid ethyl ester, also known as the ethyl ester of trans-1-amino-2-cyclohexanecarboxylic acid, is a chemical compound with the molecular formula C9H17NO2. It is a derivative of cyclohexanecarboxylic acid and is commonly used as a pharmaceutical intermediate in the production of various drugs, including anti-inflammatory and anti-cancer medications. (1S,2S)-2-aMinocyclohexanecarboxylic acid ethyl ester exists as a colorless to pale yellow liquid and is insoluble in water, but soluble in organic solvents such as ethanol and acetone. It is an important building block for the synthesis of various organic compounds and is commonly used in laboratory research and pharmaceutical manufacturing.

Upstream product

• 64-17-5 ethanol 
• 29586-50-3 (+)-(S,S)-N-benzoyl-trans-2-aminocyclohexanecarboxylic acid 
• 1436-60-8 ethyl trans-2-amino-1-cyclohexanecarboxylate 
• 1128-00-3 ethyl 2-aminocyclohex-1-ene-1-carboxylate 
• 1655-07-8 ethyl 2-oxocyclohexane carboxylate 
• 1469-49-4 6-carbamoylcyclohex-3-enecarboxylic acid 
• 6294-84-4 cis-1-carboxy-2-(aminocarboxyl)-2-cyclohexane 
• 16524-13-3 (+/-)-N-benzoyl-trans-2-aminocyclohexane-carboxylic acid 

Downstream Products

• 5691-20-3 (1RS,2SR)-2-aminocyclohexanecarboxylic acid 
• 92329-81-2 (+/-)-cis-2-(2-ethoxycarbonyl-ethylamino)-cyclohexane-carboxylic acid-⁽¹⁾-ethyl ester 
• 114772-23-5 (1R,2R)-2-Trifluoromethanesulfonylamino-cyclohexanecarboxylic acid ethyl ester 
• 24717-01-9 cis-2-aminocyclohexane-1-carboxamide 
• 110901-40-1 trans-2-aminocyclohexane-1-carboxamide 
• 24717-02-0 cis-2-aminocyclohexanecarbohydrazide 
• 114950-61-7 ethyl cis (E)-N-(p-nitrobenzylidene)-2-aminocyclohexanecarboxylate 
• 114950-61-7 ethyl(E)-N-(p-nitrobenzylidene)-trans-2-aminocyclohexanecarboxylate 
• 114745-48-1 ethyl cis-(2-heptanoylamino)-1-cyclohexanecarboxylate 
• 114745-48-1 ethyl trans-(2-heptanoylamino)-1-cyclohexanecarboxylate 
• 54867-17-3 cis-2-aminocyclohexane-N-methylcarboxamide 
• 213993-31-8 (1S,2S)-2-amino-cyclohexylmethanol 
• 5691-19-0 rac-trans-2-aminocyclohexanecarboxylic acid 
• 29586-59-2 trans-2-hydroxymethylcyclohexylamine 

Relevant articles and documents

Synthesis of oxazolidin-2-ones and imidazolidin-2-ones directly from 1,3-diols or 3-amino alcohols using iodobenzene dichloride and sodium azide

A general and efficient method for the synthesis of oxazolidin-2-ones and imidazolidin-2-ones directly from 1,3-diols and 3-amino alcohols has been developed using the same reagent combination of iodobenzene dichloride (PhICl2) and sodium azide (NaN3).

Approach to highly enantiopure β-amino acid esters by using lipase catalysis in organic media

Ethyl esters of ten alicyclic β-aminocarboxylic acids were resolved by lipase catalysis in organic solvents. The resolution was based on acylation of the amino group at the R-stereogenic centre with various 2,2,2- trifluoroethyl esters. An increase in the hydrophobic nature of the acyl donor enhanced the enantioselectivity and reactivity in the case of lipase SP 526 from Candida antarctica, while the opposite effect was observed with lipase PS from Pseudomonas cepacia. An unexceptional enantioselectivity enhancement was observed when 2,2,2-trifluoroethyl chloroacetate was used in the case of lipase PS catalysis.