29586-50-3

Upstream product

• 18886-85-6 (3aR,7aS)-2-hydroxyhexahydro-1H-isoindol-1,3(2H)-dione 
• 16524-13-3 (+/-)-N-benzoyl-trans-2-aminocyclohexane-carboxylic acid 
• 868776-23-2 methyl (1S,2S)-2-(benzoylamino)cyclohexanecarboxylate 
• 13149-00-3 1,2-cis-cyclohexanedicarboxylic anhydride 
• 100711-73-7 2-benzenesulfonyloxy-(3ar,7ac)-hexahydro-isoindole-1,3-dione 
• 1436-60-8 ethyl cis-2-amino-1-cyclohexanecarboxylate 
• 1128-00-3 ethyl 2-aminocyclohex-1-ene-1-carboxylate 
• 5691-20-3 (1RS,2SR)-2-aminocyclohexanecarboxylic acid 
• 98-88-4 benzoyl chloride 
• 118-92-3 anthranilic acid 
• 5691-19-0 trans-2-amino-1-cyclohexanecarboxylic acid 

Downstream Products

• 26693-58-3 (-)-(R,R)-N-benzoyl-trans-2-aminocyclohexanecarboxylic acid 
• 77612-22-7 E-N-benzyl-2-p-nitrophenyl-4,5-tetramethylenetetrahydro-1,3-oxazines 
• 29569-80-0 (1R,2S)-2-(hydroxymethyl)cyclohexanol 
• 1654-67-7 (1R)-trans-2-hydroxy-cyclohexanecarboxylic acid 
• 5691-19-0 (1R,2R)-2-aminocyclohexanecarboxylic Acid 
• 119068-36-9 ethyl anti-(1R,2R)-2-hydroxycyclohexanecarboxylate 
• 213993-31-8 (1S,2S)-2-amino-cyclohexylmethanol 
• 5691-19-0 rac-trans-2-aminocyclohexanecarboxylic acid 
• 24716-94-7 (1S,2S)-2-aminocyclohexanecarboxylic acid ethyl ester 
• 178737-10-5 trans-(1R,2R)-1-amino-2-hydroxymethyl-cyclohexane 
• 26849-62-7 trans-2-amino-1-cyclohexyl carboxylic acid ethyl ester 
• 77612-22-7 Z-N-benzyl-2-p-nitrophenyl-4,5-tetramethylenetetrahydro-1,3-oxazines 
• 92597-09-6 cis-5-Benzyl-3-oxa-5-azabicyclo<4.4.0>decane 
• 65325-08-8 cis-2-phenyl-4a,5,6,7,8,8a-hexahydro-3,1-benzoxazin-4-one 

Relevant academic research and scientific papers

Synthesis and microbial transformation of β-amino nitriles

Rhodococcus equi A4, Rhodococcus erythropolis NCIMB 11540 and Rhodococcus sp. R312 were investigated towards their ability to produce β-amino amides and acids from β-amino nitriles. The microorganisms show comparable trends: five-membered alicyclic 2-amino nitriles were transformed significantly faster than the six-membered compounds and the products of trans-2-amino nitriles (amides and acids) were formed considerably faster than the cis-counterparts (amides). The trans-five membered nitriles gave the amides (1b, 5b) in excellent enantiomeric excess (94-99%), the biotransformation of trans-six membered substrates resulted in the formation of the acid (3c, 7c) in excellent ee (87-99%). The ee's of the cis-compounds were throughout lower. Fifteen new substances were synthesized and characterized in the course of this work.

FUSED QUINOLINE DERIVATIVE AND USE THEREOF

The present invention aims at provision of a quinoline derivative having a neurokinin 2 (NK2) receptor antagonistic action and relates to a compound represented by the formula (I) wherein Rl is a hydrogen atom and the like; R2 is a hydrogen atom, a hydrocarbon group optionally having substituent(s) and the like; R3 is unsubstituted (i.e., absence), a hydrogen atom and the like; R4 and R5 are the same or different and each is a hydrogen atom, a hydrocarbon group optionally having substituent(s), and the like; R6is (cyclic group optionally having substituent(s)) -carbonyl, and the like; R7, R8,R9 and R10 are the same or different and each is a hydrogen atom, halogen and the like; or R7and R8,R8 and R9,and R9 and R10 may form a ring together with the adjacent carbon atoms; n is an integer of 1 to 5; --- represents unsubstituted (i.e., absence) or a single bond; and --- represents a single bond or a double bond, or a salt thereof, and the like.

Synthesis and characterization of trans-2-aminocyclohexanecarboxylic acid oligomers: An unnatural helical secondary structure and implications for β-peptide tertiary structure

The preparation, crystal structures, and circular dichroism (CD) spectra of two oligomers of optically active trans-2-aminocyclohexanecarboxylic acid are reported. In the solid state, both the tetramer and the hexamer of this β-amino acid display a helica