24736-82-1Relevant academic research and scientific papers
Base promoted regioselective aromatization for the preparation of substituted 3-hydroxybenzene dicarboxylate
Guo, Weihang,Wang, Xianheng,Zhao, Changkuo,Wang, Yuhe
, p. 3167 - 3172 (2020)
A new convenient base promoted aromatization process has been developed to prepare substituted 3-hydroxybenzene dicarboxylate using commercially available materials. In particular, regioselectivity will occur for substrates with mono-substitution at 5- or
Biosynthesis of the Enterotoxic Pyrrolobenzodiazepine Natural Product Tilivalline
Dornisch, Elisabeth,Pletz, Jakob,Glabonjat, Ronald A.,Martin, Florian,Lembacher-Fadum, Christian,Neger, Margit,H?genauer, Christoph,Francesconi, Kevin,Kroutil, Wolfgang,Zangger, Klaus,Breinbauer, Rolf,Zechner, Ellen L.
supporting information, p. 14753 - 14757 (2017/11/14)
The nonribosomal enterotoxin tilivalline was the first naturally occurring pyrrolobenzodiazepine to be linked to disease in the human intestine. Since the producing organism Klebsiella oxytoca is part of the intestinal microbiota and the pyrrolobenzodiaze
Metallo-β-lactamase inhibitory activity of 3-alkyloxy and 3-amino phthalic acid derivatives and their combination effect with carbapenem
Hiraiwa, Yukiko,Morinaka, Akihiro,Fukushima, Takayoshi,Kudo, Toshiaki
, p. 5841 - 5850 (2013/09/12)
3-Alkyloxy and 3-amino phthalic acid derivatives were found to have metallo-β-lactamase inhibitory activity. Among them, 3-amino phthalic acid derivatives showed both potent activity against metallo-β-lactamase, IMP-1 inhibitory activity and a strong combination effect with biapenem (BIPM), carbapenem antibiotic. In particular, the 4′-hydroxy-piperidine derivative showed strong IMP-1 inhibitory activity and a combination effect with various antibiotics.
