62351-79-5Relevant academic research and scientific papers
2-methyl-4-oxo-N-(4-oxo-2-phenyl substituted-1,3-thiazolidin-3-yl)-3,4- dihydroquinazoline-5-carboxamides - A new range of fluorescent whiteners: Synthesis and photophysical characterization
Patil, Vikas S.,Padalkar, Vikas S.,Sekar, Nagaiyan
, p. 1077 - 1086 (2014)
Fluorescent quinazolinones were synthesized form ethyl 2-methyl-4-oxo-3,4- dihydroquinazoline -5-carboxylate intermediate. The photophysical properties of the compounds were evaluated in DMF solvent. The experimental absorption and emission of the compoun
Synthesis of 2-methyl-5-(5-phenyl substituted-1,3,4 oxadiazole-2-yl) quinazolin-4-one fluorescent brightening agent: Computational and experimental comparison of photophysical structure
Patil, Vikas,Padalkar, Vikas S.,Sekar, Nagaiyan,Patil, Satish V.,Rajput, Jamatsing
, p. 150 - 157 (2019)
Report is about the synthesized new range of oxadiazole substituted quinazoline and studied its electronic distribution to attribute fluorescent properties. B3LYP Density Functional Theory (DFT) computational optimization was studied to observe the effect
Molecular properties of 5-(1H-Benzo[D]Oxa, thia, imid azole-2-Yl)-2-methyl quinazolin-4-ol fluorescent brighteners: Theoretical and experimental approach
Patil, Vikas,Sekar, Nagaiyan,Padalkar, Vikas S.,Rajput, Jamatsing,Patil, Sharad R.,Patil, Satish V.
, (2020)
A series of seven new fluorescent brighteners 5-(1H-benzo[d]oxazole, thiazole, imidazole-2-yl)-2-methyl quinazolin-4-ol were synthesized by chemical reaction of 2-Methyl-4-oxo-3,4-dihydroquinazoline-5-carboxylic acid and derivatives of 2-aminophenol/2-ami
FUSED TETRA OR PENTA-CYCLIC PYRIDOPHTHALAZINONES AS PARP INHIBITORS
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Page/Page column 48; 49, (2013/07/19)
Provided are certain fused tetra or penta-cyclic compounds and salts thereof, compositions thereof, and methods of use thereof.
Metallo-β-lactamase inhibitory activity of 3-alkyloxy and 3-amino phthalic acid derivatives and their combination effect with carbapenem
Hiraiwa, Yukiko,Morinaka, Akihiro,Fukushima, Takayoshi,Kudo, Toshiaki
, p. 5841 - 5850 (2013/09/12)
3-Alkyloxy and 3-amino phthalic acid derivatives were found to have metallo-β-lactamase inhibitory activity. Among them, 3-amino phthalic acid derivatives showed both potent activity against metallo-β-lactamase, IMP-1 inhibitory activity and a strong combination effect with biapenem (BIPM), carbapenem antibiotic. In particular, the 4′-hydroxy-piperidine derivative showed strong IMP-1 inhibitory activity and a combination effect with various antibiotics.
Metallo-β-lactamase inhibitory activity of phthalic acid derivatives
Hiraiwa, Yukiko,Morinaka, Akihiro,Fukushima, Takayoshi,Kudo, Toshiaki
scheme or table, p. 5162 - 5165 (2010/03/24)
4-Butyl-3-methylphthalic acid was recognized as a metallo-β-lactamase inhibitor. The structure-activity relationship study of substituted phthalic acids afforded 3-phenylphthalic acid derivatives as potent IMP-1 inhibitors. On the other hand, 3-substituted with 4-hydroxyphenyl phthalic acid derivative displayed a potent combination effect with biapenem (BIPM) against Pseudomonas aeruginosa that produce IMP-1.
Nonacid nitration of benzenedicarboxylic and naphthalenecarboxylic acid esters
Nose,Suzuki,Suzuki
, p. 4356 - 4360 (2007/10/03)
When treated with nitrogen dioxide in the presence of ozone and a catalytic amount of iron(III) chloride in inert organic solvent at -10 to +5 °C, benzenedicarboxylic acid diesters 1, 4, and 6 underwent smooth nitration to give the corresponding mononitro derivatives 2/3, 5, and 7, respectively, in good yield (kyodai nitration). Naphthalenecarboxylic acid esters 8 and 11 and naphthalene-1,8-dicarboxylic acid diester 16 were similarly nitrated in the absence of catalyst to give the expected nitro compounds 9/10, 12-15, and 17-22, respectively. Different from conventional nitration based on the combined use of concentrated nitric and sulfuric acids, no hydrolytic cleavage of the ester function was observed under these conditions. The isomer distribution has been determined for the nitration of naphthalenecarboxylic acid esters 8, 11, and 16, and spectral data were collected for less common nitro derivatives. A unique changeover of the orientation mode observed in the kyodai nitration of diester 16, from the initial exclusive meta to the final meta/para, has been discussed in terms of the competition between the electrophilic substitution process involving the nitronium ion (NO2+) and the addition-elimination sequence involving the nitrogen trioxide radical (NO3).
