24781-11-1

Basic information

• Product Name: 1-benzyl-6-methyl-2-phenyl-1H-benzo[d]imidazole
• Synonyms: 1-benzyl-6-methyl-2-phenyl-1H-benzo[d]imidazole
• CAS NO: 24781-11-1
• Molecular Weight: 298.387
• Mol File: 24781-11-1.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 1-benzyl-6-methyl-2-phenyl-1H-benzo[d]imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-6-methyl-2-phenyl-1H-benzo[d]imidazole(24781-11-1)
• EPA Substance Registry System: 1-benzyl-6-methyl-2-phenyl-1H-benzo[d]imidazole(24781-11-1)

Safety Data

• Hazardous Substances Data: 24781-11-1(Hazardous Substances Data)

Usage

Chemical class

benzimidazoles
A class of heterocyclic aromatic compounds containing a benzene ring fused to an imidazole ring.

Molecular structure

1-benzyl-6-methyl-2-phenyl-1H-benzo[d]imidazole
A derivative of benzimidazole with a benzyl group, a methyl group, and a phenyl group attached to the imidazole ring.

Heterocyclic compound

benzene ring fused to an imidazole ring
A compound containing a ring structure with at least one ring having non-carbon atoms, such as nitrogen or oxygen, in addition to carbon atoms.

Benzyl group

C6H5CH2-
A phenyl group (C6H5-) attached to a methylene group (CH2-).

Methyl group

CH3
A carbon atom bonded to three hydrogen atoms.

Phenyl group

C6H5-
A flat, unsaturated carbon ring with six carbon atoms and five hydrogen atoms.

Potential applications

pharmaceuticals and agrochemicals
The compound may be used in the development of drugs and chemicals for agricultural purposes.

Biological activities

anticancer, antiviral, and antibacterial properties
The compound exhibits properties that may help in the treatment or prevention of cancer, viral infections, and bacterial infections.

Ongoing research

exploring potential uses in various fields
Scientists are actively studying this compound to determine its possible applications and benefits in different areas.

Upstream product

• 100-44-7 benzyl chloride 
• 2963-65-7 5-methyl-2-phenyl-1H-1,3-benzimidazole 
• 71838-16-9 3-bromo-4-iodotoluene 
• 15421-92-8 N-benzylbenzamidine 
• 1402938-81-1 (Z)-N-(2-chloro-4-methylphenyl)benzimidoyl chloride 
• 100-46-9 benzylamine 
• 77791-06-1 N-(2-chloro-4-methylphenyl)benzamide 
• 98-88-4 benzoyl chloride 
• 615-65-6 2-chloro-4-methyl-benzenamine 
• 446-34-4 2-fluoro-4-methyl-1-nitrobenzene 
• 496-72-0 4-methyl-1,2-diaminobenzene 
• 100-51-6 benzyl alcohol 
• 103-49-1 dibenzylamine 
• 29540-80-5 N¹,N²-dibenzyl-4-methylbenzene-1,2-diamine 

Relevant articles and documents

Electrochemical Synthesis of Benzo[ d]imidazole via Intramolecular C(sp3)-H Amination

An electrochemical dehydrogenative amination for the synthesis of benzimidazoles was developed. This electrosynthesis method could address the limitations of the C(sp3)-H intramolecular amination synthesis reaction and provide novel access to obtain 1,2-disubstituted benzimidazoles without transition metals and oxidants. Under undivided electrolytic conditions, various benzimidazole derivatives could be synthesized, exhibiting functional group tolerance.

Heterogenizing a Homogeneous Nickel Catalyst Using Nanoconfined Strategy for Selective Synthesis of Mono- And 1,2-Disubstituted Benzimidazoles

A homogeneous Ni-phenanthroline catalyst was successfully immobilized into the cavities of a metal-organic framework, ZIF-8. The as-synthesized heterogeneous catalyst, Ni-Phen@ZIF, represents the first MOF based catalyst that enables dehydrogenative coupling of alcohols with aromatic diamines for selective synthesis of both mono- and 1,2-disubstituted benzimidazoles. The catalyst survived under harsh basic conditions, characterized by SEM, TEM, BET, PXRD, and EDX elemental mappings. The presence of the nanoconfined Ni-phenanthroline complex and the formation of extra Lewis acid sites during catalysis in the Ni-Phen@ZIF structure, confirmed by TPD analysis and kinetic experiments, might be responsible for higher activity and selectivity.

Benzimidazole compound with endothelial lipase inhibition effect and application of benzimidazole compound

The invention discloses a benzimidazole compound with an endothelial lipase inhibition effect and application of the benzimidazole compound, and belongs to the technical field of medicines. The benzimidazole compound has an excellent inhibition effect on endothelial lipase, can effectively treating atherosclerosis and sequelae thereof, such as coronary heart disease, and also promotes treatment onmetabolic syndrome and sequelae thereof, such as diabetes. The benzimidazole compound provided by the invention has good solubility in an aqueous medium, also has good biological activity and metabolic stability, and shows advantages in the aspect of serum stability.