24784-42-7

Upstream product

• 106-47-8 4-chloro-aniline 
• 123-11-5 4-methoxy-benzaldehyde 
• 1493-27-2 ortho-nitrofluorobenzene 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 51-17-2 benzoimidazole 
• 1679-18-1 4-Chlorophenylboronic acid 
• 68817-71-0 2-(4-chloroanilino)aniline 
• 100-07-2 4-methoxy-benzoyl chloride 

Relevant academic research and scientific papers

Benzimidazole bearing Pd–PEPPSI complexes catalyzed direct C2-arylation/heteroarylation of N-substituted benzimidazoles

A convenient and highly efficient palladium-catalyzed direct C2-arylation/heteroarylation of N-substituted benzimidazole derivatives such as N-benzyl/3-chlorobenzyl/2,4,6-trimethylbenzyl/2,4,6-triisopropylbenzyl/aryl benzimidazoles with various aryl/heter

Discovery of new leads against Mycobacterium tuberculosis using scaffold hopping and shape based similarity

BM212 [1,5-diaryl-2-methyl-3-(4-methylpiperazin-1-yl)-methyl-pyrrole] is a pyrrole derivative with strong inhibitory activity against drug resistant Mycobacterium tuberculosis and mycobacteria residing in macrophages. However, it was not pursued because o

One-pot sequential synthesis of 1,2-disubstituted benzimidazoles under metal-free conditions

An easy and inexpensive method has been developed to access 1,2-disubstituted benzimidazoles following a one-pot sequential coupling/reduction/cyclization process under metal-free neutral conditions.

Methods of treating or preventing interstitial cystitis

PCT No. PCT/US97/03895 Sec. 371 Date Aug. 25, 1998 Sec. 102(e) Date Aug. 25, 1998 PCT Filed Mar. 7, 1997 PCT Pub. No. WO97/33873 PCT Pub. Date Sep. 18, 1997This invention provides methods for the treatment or prevention of interstitial cystitis or urethral syndrome in a mammal which comprise administering to a mammal in need thereof an effective amount of a substituted benzimidazole, or a pharmaceutically acceptable salt or solvate thereof.

Methods of treating or preventing sleep apnea

This invention provides methods for the treatment or prevention of sleep apnea in a mammal which compris administering to a mammal in need thereof an effective amount of a substituted benzimidazole, or a pharmaceutically acceptable salt or solvate thereof.

METHODS FOR TREATING A PHYSIOLOGICAL DISORDER ASSOCIATED WITH BETA-AMYLOID PEPTIDE

This invention provides substituted benzimidazoles which are useful in treating or preventing conditions associated with beta-amyloid peptide. Some such conditions associated with beta-amyloid peptide include Alzheimer's Disease, Down's Symdrome and amyloidosis of the Dutch type

Non-peptidyl tachykinin receptor antagonists

This invention provides novel substituted benzimidazoles of formula II which are useful as tachykinin receptor antagonists. This invention also provides methods for treating a condition associated with an excess of tachykinin which comprises administering to a mammal in need thereof one of a series of substituted benzimidazoles. This invention further provides pharmaceutical formulations comprising one or more of the substituted benzimidazoles of the present invention in association with pharmaceutical carriers, diluents, or excipients. A and Ra-Re are as defined in the description.