2482-25-9

Usage

Uses

Used in Pharmaceutical Research:
4-HYDROXY-BZ-GLY-OH is used as a probe for estimating the activities of organic anion transporter 3 (OAT3) and multidrug resistance-associated protein 4 (MRP4). These proteins are responsible for mediating the efflux of organic anions from the brain and heart in mice. The compound helps researchers understand the transport mechanisms and develop potential treatments for related conditions.
Used in Neurological Applications:
In the field of neurology, 4-HYDROXY-BZ-GLY-OH is used to study the transport of organic anions across the blood-brain barrier. This understanding can be crucial for the development of drugs that target the central nervous system and require efficient crossing of this barrier.
Used in Cardiology Applications:
In cardiology, 4-HYDROXY-BZ-GLY-OH is utilized to investigate the transport of organic anions in the heart. This can aid in the development of therapies for heart-related conditions that involve the movement of these anions across cellular membranes.
Used in Drug Development:
4-HYDROXY-BZ-GLY-OH is also used in the development of drugs that target the transporters OAT3 and MRP4. By understanding the interaction between these transporters and the compound, researchers can design drugs that are more effective in crossing cellular barriers and reaching their target sites.

InChI:InChI=1/C9H9NO4/c11-7-3-1-6(2-4-7)9(14)10-5-8(12)13/h1-4,11H,5H2,(H,10,14)(H,12,13)

Upstream product

• 7364-42-3 N,O-bis(trimethylsilyl)glycine 
• 70799-65-4 4-(trimethylsilyloxy)benzoyl chloride 
• 100-09-4 4-methoxybenzoic acid 
• 28141-24-4 4-hydroxybenzoyl chloride 
• 56-40-6 glycine 
• 14180-11-1 4-(methoxycarbonyloxy)benzoic acid 
• 99-96-7 4-hydroxy-benzoic acid 
• 2078-13-9 4-[(trimethylsilyl)oxy]benzoic acid trimethylsilyl ester 
• 62086-71-9 (4-methoxybenzoylamino)acetic acid methyl ester 
• 861570-35-6 N-(4-methoxycarbonyloxy-benzoyl)-glycine ethyl ester 

Downstream Products

• 98589-33-4 N-(4-hydroxy-3,5-diiodo-benzoyl)-glycine 
• 109865-78-3 2-(4-acetoxy-phenyl)-4-(4-dimethylamino-benzylidene)-4H-oxazol-5-one 
• 56-40-6 glycine 
• 99-96-7 4-hydroxy-benzoic acid 
• 13214-64-7 N-(4-methoxybenzoyl)glycine 

Relevant academic research and scientific papers

A Facile and Efficient Synthesis of 4-Arylidene-2-phenyl-5(4H)-oxazolones and Their Antimicrobial Evaluation against Selected Human and Phytopathogens

A simple and convenient method has been developed for the synthesis of a series of 2-(4-substituted phenyl)-4-(substituted arylidene)-1,3-oxazol-5-ones (5a–j) via reactions of hippuric acid with differently substituted aromatic aldehydes (4a–j) in sodium acetate, potassium acetate, calcium acetate, and ammonium acetate, respectively, which were tested for their efficiency as catalysts in both conventional and microwave-assisted synthetic methods in presence of 4 ? zeolites. The title compounds were evaluated for their antimicrobial properties against selected human pathogens (bacterial and fungal) and phytopathogens (fungal) and were compared with standard drugs. The results of the study are reported.

Substrate Specificity and Stoichiometry of Nα-Benzyloxycarbonyl Amino Acid Urethane Hydrolase from Streptococcus faecalis R ATCC 8043

The substrate specificity of a new enzyme, Nα-benzyloxycarbonyl amino acid urethane hydrolase, was investigated.The enzyme hydrolyzed Nα-benzyloxycarbonyl-glycine and -alanine, and Nα-benzoyl-glycine and -alanine.Nα-benzyloxycarbonyl-glycine was hydrolyzed to give equimolar benzyl alcohol and glycine.Equimolar benzoic acid and glycine were produced from Nα-benzoyl-glycine by the enzyme reaction.The Km, k0, and k0/Km values were measured for several substrates.The k0 values varied widely with the amino acid residues.Nα-benzyloxycarbonyl-glycine and Nα-benzoyl-glycine produced relatively small changes in the Km values (0.36 ca. 0.10 mM) and the k0/Km values (99440 ca. 202000 M-1 sec-1).The rate of hydrolysis is significantly affected by electron-supplying substituents on the benzene ring.

Syntheses and Reactions of (Trimethylsiloxy)benzoyl Chlorides

The (trimethylsiloxy)benzoyl chlorides 1-7 are easily to obtain under mild conditions from silylated hydroxybenzoic acids by means of thionyl chloride.Whereas these acid chlorides are stable at room temperature, they undergo condensation polymerisation at temperatures above 100 deg C.Reactions with various nucleophils, such as thioalcohols, phenols, amines, N,O-bis(silylated)amino acids and N-silylated lactams were investigated.With hexamethyldisilazane and thionyl chloride the (trimethylsiloxy)benzonitriles 21, 22 are accessible, and by means of trimethylsilylazide the (trimethylsiloxy)phenyl isocyanates 23-25 were obtained.Conversion with phenyl carbazate and subsequent silylation lead to the 2-(trimethylsiloxy)phenyl-1,3,4-oxadiazol-5-ones 27a-c.