24836-10-0Relevant academic research and scientific papers
Transition metal-free cyclization of N-boc-N-propargylenamines
Chikayuki, Yuya,Higashiyama, Kimio,Ishikawa, Haruka,Kouno, Yasuaki,Sasaki, Shigeru,Teramoto, Hiroyoshi,Waki, Yoko,Yamauchi, Takayasu,Yonekawa, Shiori
, p. 719 - 746 (2020/07/13)
An efficient method for the synthesis of multi-substituted pyrroles was developed using basic cyclization of readily accessible N-Boc-N-propargylenamines. Despite the basic conditions, cleavage of the N-Boc group occurred easily. The process was rapid and afforded N-H-pyrroles with wide functional group tolerance in high yields.
Versatility of Weinreb amides in the Knorr pyrrole synthesis
Alberola, Angel,Ortega, Alfonso Gonzalez,Sadaba, M. Luisa,Sanudo, Carmen
, p. 6555 - 6566 (2007/10/03)
N-Methoxy-N-methyl-α-enaminocarboxamides were prepared starting from enamines and Weinreb α-aminoamides. Their reaction with oganometallic compounds and subsequent cyclization constitute a versatile alternative in the Knorr pyrrole synthesis.
