24852-71-9

Upstream product

• 100-44-7 benzyl chloride 
• 118-92-3 anthranilic acid 
• 100-53-8 phenylmethanethiol 
• 552-89-6 2-nitro-benzaldehyde 
• 446-52-6 2-Fluorobenzaldehyde 
• 153511-19-4 S-(2-formylphenyl) N,N-dimethylthiocarbamate 
• 90-02-8 salicylaldehyde 
• 100-39-0 benzyl bromide 
• 6630-33-7 ortho-bromobenzaldehyde 
• 89-98-5 2-chloro-benzaldehyde 
• 51471-69-3 2-Benzylmercapto-benzoesaeure-hydrazid 
• 4521-31-7 o-hydroxymethyl thiophenol 
• 4892-02-8 Methyl thiosalicylate 
• 58435-43-1 2-methoxycarbonyl-1-benzylthiobenzene 

Downstream Products

• 356790-10-8 PhCH₂SC₆H₄-2-CHNC₆H₅ 
• 93023-22-4 2-Amino-1-<2-benzylmercapto-phenyl>-propan 
• 150562-56-4 2-[2-[(phenylmethyl)thio]phenyl]-4(1H)-quinolinone 
• 1087010-11-4 2-(1,1-dioxo-2-phenyl-2,3-dihydro-1H-benzo[b]thiophen-3-yl)acetic acid methyl ester 
• 1087010-13-6 2-(1,1-dioxo-2-phenyl-2,3-dihydro-1H-benzo[b]thiophen-3-yl)acetic acid 
• 1087009-21-9 2-(1,1-dioxo-2-phenyl-2,3-dihydro-1H-benzo[b]thiophen-3-yl)-N-hydroxyacetamide 
• 131327-53-2 ethyl 3-(2-benzylthio)phenyl-2-diazo-3-hydroxypropanoate 
• 92963-27-4 2-Nitro-1-(2-benzylmercapto-phenyl)-propen-⁽¹⁾ 
• 29199-11-9 2-formylthiophenol 
• 1198110-42-7 5-[2-(benzylsulfanyl)benzylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 1173993-82-2 2-(benzylsulfonyl)benzaldehyde 
• 87488-99-1 5-[(2-phenylmethylthio)phenyl]oxazole 
• 120571-35-9 ethyl 1-benzyl-2,3-dihydro-3-oxobenzothiophene-1-oxide-2-carboxylate, inner salt 

Relevant academic research and scientific papers

Synthesis and characterization of triosmium clusters containing the 2-(benzylthio)benzoyl ligand

Reaction of with an equimolar proportion of 2-(benzylthio)-benzaldehyde (1) gives three new compounds: two yellow isomers of (2a and 2b) and an orange crystalline compound (3).The mol

Histidine-functionalized chitosan-Cu(II) complex: A novel and green heterogeneous nanocatalyst for two and three component C-S coupling reactions

Using a fixing Cu2+ NP reaction on histidine modified chitosan, a novel applicable matrix was successfully prepared and investigated as a heterogeneous nanocatalyst for preparing diaryl sulfides and aryl benzyl thioethers. The Cu(ii)-his@CS nanocatalyst was characterized by FT-IR, CHN, XRD, FE-SEM, TEM, EDX, ICP-AES and TG analysis. This novel copper nanocatalyst was used for two and three component C-S coupling reactions of different aryl halides. The nanocatalyst showed high catalytic activity and reusability in both reactions.

Compounds Having CRTH2 Antagonist Activity

Compounds of general formula (I) W is chloro or fluoro; Z is a —SO2YR1 group wherein R1 is C3-C8 heterocyclyl, aryl or heteroaryl any of which may optionally be substituted with one or more substituents selected from halo, —CN, —C1-C6 alkyl, —SOR3, —SO2R3, —SO2N(R2)2, —N(R2)2, —NR2C(O)R3, —CO2R2, —CONR2R3, —NO2, —OR2, —SR2, —O(CH2)pOR2, and —O(CH2)pO(CH2)qOR2 wherein each R2 is independently hydrogen, —C1-C6 alkyl, —C3-C8 cycloalkyl, aryl or heteroaryl;each R3 is independently, —C1-C6 alkyl, —C3-C8 cycloalkyl, aryl or heteroaryl;p and q are each independently an integer from 1 to 3; Y is a straight or branched C1-C4 alkylene chain; and their pharmaceutically acceptable salts, hydrates, solvates, complexes or prodrugs are useful in orally administrable compositions for the treatment of allergic diseases such as asthma, allergic rhinitis and atopic dermatitis.

Substituted 2-(3′,4′,5′-trimethoxybenzoyl)-benzo[b] thiophene derivatives as potent tubulin polymerization inhibitors

The central role of microtubules in cell division and mitosis makes them a particularly important target for anticancer agents. On our early publication, we found that a series of 2-(3′,4′,5′-trimethoxybenzoyl)-3- aminobenzo[b]thiophenes exhibited strong antiproliferative activity in the submicromolar range and significantly arrested cells in the G2-M phase of the cell cycle and induced apoptosis. In order to investigate the importance of the amino group at the 3-position of the benzo[b]thiophene skeleton, the corresponding 3-unsubstituted and methyl derivatives were prepared. A novel series of inhibitors of tubulin polymerization, based on the 2-(3,4,5-trimethoxybenzoyl)-benzo[b]thiophene molecular skeleton with a methoxy substituent at the C-4, C-5, C-6 or C-7 position on the benzene ring, was evaluated for antiproliferative activity against a panel of five cancer cell lines, for inhibition of tubulin polymerization and for cell cycle effects. Replacing the methyl group at the C-3 position resulted in increased activity compared with the corresponding 3-unsubstituted counterpart. The structure-activity relationship established that the best activities were obtained with the methoxy group placed at the C-4, C-6 or C-7 position. Most of these compounds exhibited good growth inhibition activity and arrest K562 cells in the G2-M phase via microtubule depolymerization.

Preparation and structure of some sulfanylpropenylidene derivatives of Meldrum's acid

Condensation of Meldrum's acid with the 3-sulfanylpropenal derivatives 7a and 7b gives the 3-sulfanylpropenylidene derivatives 2a and 2b, respectively. NMR and X-ray analysis of 2a and 2b show that the electron-donating group conjugates with the electron-

COMPOUNDS HAVING CRTH2 ANTAGONIST ACTIVITY

Compounds of general formula (I) W is chloro or fluoro; Z is a -SO2YR1 group wherein R1 is C3-C8 heterocyclyl, aryl or heteroaryl any of which may optionally be substituted with one or more substituen

BICYCLOSULFONYL ACID (BCSA) COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS

This invention pertains generally to the field of therapeutic compounds, and more particularly, to certain bicyclosulfonyl acid (BCSA) compounds which act as inhibitors of Tumour Necrosis Factor-α Converting Enzyme (TACE). The compounds are useful in the

Synthesis, characterization, and X-ray structural analysis of some half-sandwich ruthenium(II) arene complexes with new N,S-donor Schiff base ligands

A series of cationic, half-sandwich ruthenium complexes with the general formula [(η6-arene)RuCl(R1S-C6H4-2-CH{double bond, long}NR2)]+ (arene = p-cymene or hexamethylbenzene; R1

Synthesis of substituted dihydrobenzothiopyrans and dihydrobenzopyrans by cation-mediated cyclisation reactions

Treatment with acid of thiosalicylaldehyde- and salicylaldehyde-derived phenyl 3-phenyl-2-propenyl thioethers and ethers possessing latent oxonium ion functionality triggers simple or tandem cyclisation to give substituted dihydrobenzothiopyrans and dihyd

Gas-phase cyclisation reactions of 1-(2-arylthiophenyl)alkaniminyl and 2-(aryliminomethyl)thiophenoxyl radicals

Flash vacuum pyrolysis (FVP) of the oxime ethers 12-14 and of the sulfides 18-20 at 650°C (10-2-10-3 Torr) gave products derived from the corresponding iminyl and thiophenoxyl radicals. In all cases, benz[d]isothiazoles (e.g., 26) are formed as major products via SHi mechanisms though the yields are greatest with the iminyl precursors. Alternative pathways observed from the thiophenoxyls in specific cases include the formation of the anilinobenzothiophene 36 and of dibenzothiophene 23, via an SHi process and a spirodienyl rearrangement, respectively. There is no evidence for signicant interconversion of the iminyl and thiophenoxyl species.