24852-71-9Relevant articles and documents
Synthesis and characterization of triosmium clusters containing the 2-(benzylthio)benzoyl ligand
Lee, Siu-Ming,Cheung, Kung-Kai,Wong, Wing-Tak
, p. 273 - 278 (1995)
Reaction of with an equimolar proportion of 2-(benzylthio)-benzaldehyde (1) gives three new compounds: two yellow isomers of (2a and 2b) and an orange crystalline compound (3).The mol
Substituted 2-(3′,4′,5′-trimethoxybenzoyl)-benzo[b] thiophene derivatives as potent tubulin polymerization inhibitors
Romagnoli, Romeo,Baraldi, Pier Giovanni,Carrion, Maria Dora,Cruz-Lopez, Olga,Tolomeo, Manlio,Grimaudo, Stefania,Cristina, Antonietta Di,Pipitone, Maria Rosaria,Balzarini, Jan,Brancale, Andrea,Hamel, Ernest
experimental part, p. 5114 - 5122 (2010/09/14)
The central role of microtubules in cell division and mitosis makes them a particularly important target for anticancer agents. On our early publication, we found that a series of 2-(3′,4′,5′-trimethoxybenzoyl)-3- aminobenzo[b]thiophenes exhibited strong antiproliferative activity in the submicromolar range and significantly arrested cells in the G2-M phase of the cell cycle and induced apoptosis. In order to investigate the importance of the amino group at the 3-position of the benzo[b]thiophene skeleton, the corresponding 3-unsubstituted and methyl derivatives were prepared. A novel series of inhibitors of tubulin polymerization, based on the 2-(3,4,5-trimethoxybenzoyl)-benzo[b]thiophene molecular skeleton with a methoxy substituent at the C-4, C-5, C-6 or C-7 position on the benzene ring, was evaluated for antiproliferative activity against a panel of five cancer cell lines, for inhibition of tubulin polymerization and for cell cycle effects. Replacing the methyl group at the C-3 position resulted in increased activity compared with the corresponding 3-unsubstituted counterpart. The structure-activity relationship established that the best activities were obtained with the methoxy group placed at the C-4, C-6 or C-7 position. Most of these compounds exhibited good growth inhibition activity and arrest K562 cells in the G2-M phase via microtubule depolymerization.
Preparation and structure of some sulfanylpropenylidene derivatives of Meldrum's acid
Crawford, Lynne A.,Mcnab, Hamish
experimental part, p. 995 - 1009 (2010/03/01)
Condensation of Meldrum's acid with the 3-sulfanylpropenal derivatives 7a and 7b gives the 3-sulfanylpropenylidene derivatives 2a and 2b, respectively. NMR and X-ray analysis of 2a and 2b show that the electron-donating group conjugates with the electron-
