2488-53-1

Usage

Uses

Used in Pharmaceutical Industry:
4-(Difluoromethylsulfonyl)chlorobenzene is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and reactivity contribute to the development of new drugs with improved therapeutic properties and efficacy.
Used in Agrochemical Industry:
In the agrochemical sector, 4-(Difluoromethylsulfonyl)chlorobenzene serves as an essential building block for the creation of novel agrochemicals. Its incorporation into these compounds can enhance their performance, selectivity, and environmental compatibility.
Used in Specialty Chemicals Industry:
4-(Difluoromethylsulfonyl)chlorobenzene is utilized as an intermediate in the production of specialty chemicals, such as dyes and polymers. Its presence in these compounds can alter their properties, leading to the development of innovative materials with specific characteristics and applications.
Used in Organic Synthesis:
4-(Difluoromethylsulfonyl)chlorobenzene is employed as a versatile reagent in organic synthesis, enabling the construction of complex organic molecules with diverse functional groups. Its reactivity and ability to modify the properties of the resulting products make it a valuable component in the synthesis of advanced organic compounds.
It is crucial to handle and use 4-(Difluoromethylsulfonyl)chlorobenzene with proper safety precautions and in a controlled environment to minimize potential hazards to health and the environment.

InChI:InChI=1/C7H5ClF2O2S/c8-5-1-3-6(4-2-5)13(11,12)7(9)10/h1-4,7H

Upstream product

• 2488-66-6 1-chloro-4-[(difluoromethyl)sulfanyl]benzene 
• 106-54-7 p-Chlorothiophenol 
• 92022-89-4 4-chloro-benzenesulfonic acid benzylidenehydrazide 
• 275818-95-6 sodium difluoromethanesulfinate 
• 673-41-6 p-chlorobenzenediazonium tetrafluoroborate 
• 380859-96-1 ethyl 2-((4-chlorophenyl)thio)-2,2-difluoroacetate 
• 75-45-6 Chlorodifluoromethane 
• 14752-66-0 sodium p-chlorobenzenesulphinate 
• 637-87-6 1-Chloro-4-iodobenzene 

Downstream Products

• 2488-54-2 1-chloro-4-((difluoromethyl)sulfonyl)-2-nitrobenzene 
• 4837-28-9 (4-((difluoromethyl)sulfonyl)phenyl)hydrazine 
• 403496-62-8 p-chlorophenyl chlorodifluoromethyl sulfone 
• 403496-61-7 4-chlorophenyl bromodifluoromethyl sulfone 
• 935426-22-5 (p-chlorophenylsulfonyl)difluoromethyl iodide 
• 55391-51-0 4-(Difluoro-methanesulfonyl)-2-nitro-phenylamine 

Relevant academic research and scientific papers

Method for constructing fluorine-containing methyl sulfone compound through multi-component coupling

The invention discloses a fluorine-containing methyl sulfone compound as shown in a formula (1) and a synthesis method thereof. Aromatic iodide (aryl iodide or heteroaryl iodide), an inorganic sulfur reagent and a fluorine-containing building block are used as reaction raw materials and react in a solvent under the action of alkali, a catalyst and an additive to obtain a series of fluorine-containing methyl sulfone compounds. According to the invention, the fluorine-containing sulfone compound is constructed by a one-pot two-step method by taking an inorganic sulfur reagent as a sulfur source under a catalytic condition, so that the defects of the traditional synthesis of a fluorine-containing sulfone compound by thioether oxidation are avoided. According to the synthesis strategy developed by the invention, some clinical methyl sulfone drugs can be modified, and monofluoro, difluoro and trifluoromethyl sulfone compounds can be successfully obtained, which have huge potential in the field of drug development in the future.

Preparation method of difluoromethyl sulfone compound

The invention discloses a preparation method of a difluoromethyl sulfone compound. The invention provides a preparation method of a difluoromethyl sulfone compound, which comprises the following step:in a solvent, in the presence of alkali and a phase transfer catalyst, carrying out difluoromethylation reaction shown in the specification on sulfinic acid and/or salt thereof and CHClF2 to obtain the difluoromethyl sulfone compound. The solvent is a mixed solvent of water and an organic solvent; The sulfinic acid and/or salt thereof comprises positive ions and negative ions, and the negative ions contain structural fragments shown as a formula I; and the difluoromethyl sulfone compound contains a structural fragment as shown in a formula II which is described in the specification. The preparation method provided by the invention has the advantages of accessible raw materials, wide substrate range, mild reaction conditions and simple operation, can implement separation without column chromatography, and is suitable for industrial production. The difluoromethyl sulfone compound can be obtained at a high yield.

Efficient asymmetric synthesis of aryl difluoromethyl sulfoxides and their use to access enantiopure α-difluoromethyl alcohols

The -CHF2 moiety has shown a growing interest in pharmaceutical and agrochemical applications over the last few years. Its introduction is therefore a current research topic for organic chemists. Several groups have reported the synthesis of di

Copper-Mediated Di- and Monofluoromethanesulfonylation of Arenediazonium Tetrafluoroborates: Probing the Fluorine Effect

A copper-mediated di- and monofluoromethanesulfonylation of arenediazonium tetrafluoroborates using di- and monofluoromethanesulfinate reagents provides aryl difluoromethyl (or monofluoromethyl) sulfones in good yields. It was found that the relative reactivity of these sodium fluoroalkanesulfinates in the present reactions decreases in the following order: CH2FSO2Na > CF2HSO2Na > CF3SO2Na.

Difluoromethylation of: N -arylsulfonyl hydrazones with difluorocarbene leading to difluoromethyl aryl sulfones

The difluoromethylation of N-arylsulfonyl hydrazones with difluorocarbene generated from difluoromethylene phosphobetaine (Ph3P+CF2CO2-) to give various difluoromethyl aryl sulfones is described.