24900-69-4

Basic information

• Product Name: 4-[(4-FLUOROPHENYL)SULFANYL]ANILINE
• Synonyms: 4-[(4-FLUOROPHENYL)SULFANYL]ANILINE;4-(4-FLUOROPHENYLTHIO)ANILINE;4-AMINO-4'-FLUORODIPHENYL THIOETHER;4-[(4-fluorophenyl)sulfanyl]phenylamine;4-(4-Fluorophenylthio)aniline97%
• CAS NO: 24900-69-4
• Molecular Formula: C₁₂H₁₀FNS
• Molecular Weight: 219.28
• Mol File: 24900-69-4.mol

Chemical Properties

• Melting Point: 60-62°C
• Boiling Point: 390.9°Cat760mmHg
• Flash Point: 190.2°C
• Appearance: /
• Density: 1.27g/cm³
• Vapor Pressure: 2.56E-06mmHg at 25°C
• Refractive Index: 1.653
• CAS DataBase Reference: 4-[(4-FLUOROPHENYL)SULFANYL]ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(4-FLUOROPHENYL)SULFANYL]ANILINE(24900-69-4)
• EPA Substance Registry System: 4-[(4-FLUOROPHENYL)SULFANYL]ANILINE(24900-69-4)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 24900-69-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-[(4-Fluorophenyl)sulfanyl]aniline is used as a reagent for the synthesis of pharmaceutical drugs, contributing to the development of new medications due to its ability to form complex molecular structures.
Used in Agricultural Industry:
In the agricultural sector, 4-[(4-Fluorophenyl)sulfanyl]aniline is utilized as a component in the creation of agrochemicals, potentially enhancing crop protection and yield through its integration into various compounds.
Used in Chemical Industry:
Within the chemical industry, 4-[(4-Fluorophenyl)sulfanyl]aniline serves as a precursor for the production of various organic compounds, facilitating the synthesis of a range of chemical products.
It is crucial to handle 4-[(4-Fluorophenyl)sulfanyl]aniline with care due to its potential hazards if not properly managed, ensuring safety in its applications across different fields.

InChI:InChI=1/C12H10FNS/c13-9-1-5-11(6-2-9)15-12-7-3-10(14)4-8-12/h1-8H,14H2

Upstream product

• 405-31-2 bis(4-fluorophenyl)disulfide 
• 62-53-3 aniline 
• 371-42-6 4-Fluorothiophenol 
• 2266-41-3 4-fluorobenzenesulfonylhydrazide 
• 100-00-5 4-chlorobenzonitrile 
• 2438-85-9 4-fluorophenyl 4′-nitrophenyl sulfide 

Downstream Products

• 62676-79-3 C,C,C-Trifluoro-N-[4-(4-fluoro-phenylsulfanyl)-phenyl]-methanesulfonamide 
• 90309-32-3 N-[4-[(4-Fluorophenyl)thio]phenyl]acetamide 
• 1421707-06-3 [1'-[(E)-cinnamyl]-5-(4-fluorophenyl)sulfanylspiro[indoline-3,4'-piperidine]-1-yl]-(2-methyl-4-pyridyl)methanone 
• 1421707-26-7 (2-chloro-6-methyl-4-pyridyl)-[1'-[(E)-cinnamyl]-5-(4-fluorophenyl)sulfanylspiro[indoline-3,4'-piperidine]-1-yl]methanone 
• 1421707-07-4 (2-chloro-4-pyridyl)-[1'-[(E)-cinnamyl]-5-(4-fluorophenyl)sulfanylspiro[indoline-3,4'-piperidine]-1-yl]methanone 
• 1421708-21-5 benzyl 5-(4-fluorophenyl)sulfanyl-1-(2-methylpyridine-4-carbonyl)spiro[indoline-3,4'-piperidine]-1'-carboxylate 
• 1421708-20-4 benzyl 1-(2-chloro-6-methyl-pyridine-4-carbonyl)-5-(4-fluorophenyl)sulfanylspiro[indoline-3,4'-piperidine]-1'-carboxylate 
• 1421708-19-1 benzyl 1-(2-chloropyridine-4-carbonyl)-5-(4-fluorophenyl)sulfanylspiro[indoline-3,4'-piperidine]-1'-carboxylate 
• 1421708-18-0 benzyl 5-(4-fluorophenyl)sulfanylspiro[indoline-3,4'-piperidine]-1'-carboxylate 
• 1155798-47-2 1-(2,6-diisopropylphenyl)-3-[4-(4-fluorophenylsulfanyl)phenyl]-urea 

Relevant articles and documents

Iodine/DMSO-Promoted Selective Direct Arylthiation of Anilines with Thiols under Metal-Free Conditions

An iodine-promoted divergent thiolation of unprotected anilines with thiols for the synthesis of sulfide anilines has been described. The combinational use of I2 and DMSO played an important role to realize this kind of transformation without the aid of a

TBAI-mediated sulfenylation of arenes with arylsulfonyl hydrazides in DPDME

An efficient TBAI (tetrabutylammonium iodide)-mediated C–H sulfenylation of arenes with arylsulfonyl hydrazides in dipropylene glycol dimethyl ether (DPDME) was described. Various electron-rich arenes were applicable in the reaction, such as naphthylamine, naphthol, aniline, indole, pyrrole, and imidaz o [1,2-a] pyridine. A wide range of the aryl sulfides were obtained with good functional group tolerance. This method features green reaction conditions (odorless and easily available sulfur reagent, recyclable TBAI, and DPDME as solvent), and broad substrate scope. The synthetic potential is demonstrated by gram-scale synthesis and downstream transformations. The mechanism studies show that the reaction is achieved through electrophilic substitution process, and diaryl disulfide may be the main intermediate.

Flavin/I2 catalyzed aerobic oxidative C–H sulfenylation of anilines

A flavin/I2 catalyzed aerobic oxidative C–H sulfenylation of anilines with thiols under mild reaction conditions is presented for the first time. This metal-free reaction provides an atom-economic pathway to prepare various aryl sulfides with outstanding functional group compatibility. Moreover, it consumes molecular oxygen as the only terminal oxidant and produces environmentally-friendly H2O as the only byproduct.

Method for synthesis of diaryl thioether compound without transition metal catalysis

The invention discloses a method for synthesis of a diaryl thioether compound without transition metal catalysis. The method includes: in the presence of a riboflavin catalyst, an iodine source, and an oxidant, reacting a compound shown as formula (1) or a compound shown as formula (4) with a compound shown as formula (2) in a solvent at 30-100DEG C for 1-40h, and subjecting the reaction solutionto post-treatment to obtain the diaryl thioether compound shown as formula (3) or formula (5). The reaction equation is shown as the specification, in the formula (1)-formula (5), R1 is selected fromC1-C4 alkyl, aryl, C1-C4 alkoxy, halogen, halogen-substituted C1-C4 alkyl, aryl, nitro, cyano, amino, or heterocyclic mercaptan; R2, R3, and R4 are independently selected from one of H, C1-C4 alkyl, halogen-substituted C1-C4 alkyl, and aryl respectively; R5 and R6 are independently selected from C1-C4 alkyl respectively, and Y represents element O. The method provided by the invention uses a riboflavin catalyst to replace a transition metal to synthesize the diaryl thioether compound, and has the advantages of green reaction, mild conditions, good substrate universality, high yield and the like.

NOVEL SPIROINDOLINE COMPOUNDS

This invention relates to novel spiroindoline compounds of formula (I) that are generally useful as medicaments, more specifically as medicaments for animals. The medicament can preferably be used for the treatment of helminth infections and the treatment of parasitosis, such as caused by helminth infections. This invention also relates to uses of the compounds to make medicaments and treatments comprising the administration of the compounds to animals in need of the treatments. This invention also relates to the preparation of said compounds. Moreover this invention relates to pharmaceutical compositions and kits comprising the compounds.

FeF3/i2-catalyzed synthesis of 4-chalcogen- substituted arylamines by direct thiolation of an arene C-H bond

An efficient regioselective synthesis of 4-chalcogen-substituted-arylamines by FeF3-catalyzed sulfenylation and selenation of arylamines has been developed. In the presence of FeF3and I2, a variety of arylamines underwent the reaction with disulfides or diselenides to afford the corresponding 4-sulfenyl-or 4-selenenyl-arylamines in moderate to good yields. Georg Thieme Verlag Stuttgart.

2-Amino-4'(phenylsulfonyl) acetanilides

A method of modulating the immune response system in a warm-blooded animal by the administration of N-substituted-phenylthioanilines, N-substituted-phenylsulfinylanilines, and N-substituted-phenylsulfonylanilines, certain of which are new compounds.