2438-85-9

Usage

Uses

Used in Organic Synthesis:
1-Fluoro-4-[(4-nitrophenyl)sulfanyl]benzene is used as a key intermediate in organic synthesis for the production of various pharmaceuticals, agrochemicals, and other specialty chemicals. Its unique functional groups, including fluoro, nitro, and sulfanyl, contribute to its reactivity and versatility in chemical reactions, enabling the synthesis of a wide range of target compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 1-Fluoro-4-[(4-nitrophenyl)sulfanyl]benzene is used as a building block for the development of novel drug candidates. Its distinct chemical structure allows for the creation of molecules with potential therapeutic properties, such as antimicrobial, antiviral, or anticancer activities. 1-FLUORO-4-[(4-NITROPHENYL)SULFANYL]BENZENE's functional groups can be further modified to optimize its pharmacological properties and improve its efficacy and safety.
Used in Agrochemical Industry:
1-Fluoro-4-[(4-nitrophenyl)sulfanyl]benzene is also utilized in the agrochemical industry for the synthesis of new pesticides and herbicides. Its unique structure and functional groups can be tailored to target specific pests or weeds, offering potential advantages over existing products in terms of selectivity, environmental impact, and resistance management.
Used in Research and Development:
In the field of research and development, 1-Fluoro-4-[(4-nitrophenyl)sulfanyl]benzene serves as a valuable compound for studying the effects of fluorination, nitration, and sulfanylation on the properties and reactivity of organic molecules. Its complex structure provides a platform for exploring new reaction pathways, understanding the role of functional groups in molecular recognition, and developing innovative synthetic strategies.
Overall, 1-Fluoro-4-[(4-nitrophenyl)sulfanyl]benzene is a versatile and valuable chemical compound with a wide range of applications in various industries, including organic synthesis, pharmaceuticals, agrochemicals, and research and development. Its unique structure and functional groups make it an essential component in the development of new molecules with potential therapeutic, agricultural, and scientific applications.

Upstream product

• 132130-83-7 potassium p-fluorobenzenethiolate 
• 100-00-5 4-chlorobenzonitrile 
• 371-42-6 4-Fluorothiophenol 
• 586-78-7 para-nitrophenyl bromide 
• 100-32-3 di(p-nitrophenyl) disulfide 
• 823-85-8 4-fluorophenyhydrazine hydrochloride 
• 350-46-9 4-Fluoronitrobenzene 
• 636-98-6 p-nitrobenzene iodide 

Downstream Products

• 24900-69-4 4-(4-fluorophenyl)sulfanylaniline 
• 312-35-6 4-[(4-fluorophenyl)sulfonyl]benzeneamine 
• 1421708-18-0 benzyl 5-(4-fluorophenyl)sulfanylspiro[indoline-3,4'-piperidine]-1'-carboxylate 
• 1421708-19-1 benzyl 1-(2-chloropyridine-4-carbonyl)-5-(4-fluorophenyl)sulfanylspiro[indoline-3,4'-piperidine]-1'-carboxylate 
• 1421708-20-4 benzyl 1-(2-chloro-6-methyl-pyridine-4-carbonyl)-5-(4-fluorophenyl)sulfanylspiro[indoline-3,4'-piperidine]-1'-carboxylate 
• 1421708-21-5 benzyl 5-(4-fluorophenyl)sulfanyl-1-(2-methylpyridine-4-carbonyl)spiro[indoline-3,4'-piperidine]-1'-carboxylate 
• 1421707-07-4 (2-chloro-4-pyridyl)-[1'-[(E)-cinnamyl]-5-(4-fluorophenyl)sulfanylspiro[indoline-3,4'-piperidine]-1-yl]methanone 
• 1421707-26-7 (2-chloro-6-methyl-4-pyridyl)-[1'-[(E)-cinnamyl]-5-(4-fluorophenyl)sulfanylspiro[indoline-3,4'-piperidine]-1-yl]methanone 
• 1421707-06-3 [1'-[(E)-cinnamyl]-5-(4-fluorophenyl)sulfanylspiro[indoline-3,4'-piperidine]-1-yl]-(2-methyl-4-pyridyl)methanone 
• 16447-86-2 4-<18F>-fluoronitrobenzene 
• 383-24-4 1-fluoro-4-((4-nitrophenyl)sulfonyl)benzene 

Relevant academic research and scientific papers

Synthesis of diaryl sulfides based on copper-doped OMS-2

We describe a practical protocol for efficiently preparing diaryl sulfide compounds using Cu–OMS-2 as the catalyst. Cu–OMS-2 originates from manganese oxide octahedral molecular sieves modified with copper ions and catalyzes the C–S coupling reaction of substituted thiophenols and aryl halides. This protocol has the advantages of environmental friendliness, simple operation, high yields, good tolerance of functional groups, and the Cu–OMS-2 catalytic material can be recycled several times.

Method for synthesizing diarylthioether compound by using manganese oxide molecular sieve doped copper catalyst

The invention relates to a synthesis method of a diarylthioether compound by catalyzing with heterogeneous manganese oxide octahedral molecular sieve doped copper (Cu-OMS-2). The chemical structural formula of the compound is shown in the description, whe

Cerium catalyst promoted C-S cross-coupling: Synthesis of thioethers, dapsone and RN-18 precursors

In this work, we present a novel, efficient and green methodology for the synthesis of thioethers by the C-S cross-coupling reaction with the assistance of [Ce(l-Pro)2]2Ox as a heterogeneous catalyst in good to excellent yields. A scale-up of the protocol was explored using an unpublished methodology for the synthesis of a dapsone-precursor, which proved to be very effective over a short time. The catalyst [Ce(l-Pro)2]2Ox was recovered and it was shown to be effective for five more reaction cycles.

Transition-Metal-Free and Oxidant-Free Cross-Coupling of Arylhydrazines with Disulfides: Base-Promoted Synthesis of Unsymmetrical Aryl Sulfides

A novel synthesis of unsymmetrical aryl sulfides, which requires no transition metal catalyst and no oxidant, was developed. This base-promoted cross-coupling reaction proceeded using arylhydrazines and 1 equiv amount of disulfides under inert gas conditions to afford the unsymmetrical aryl sulfides in good yields.

Facile aromatic nucleophilic substitution (SNAr) reactions in ionic liquids: An electrophile-nucleophile dual activation by [Omim]Br for the reaction

A facile aromatic nucleophilic substitution (SNAr) reaction in recyclable [Omim]Br under relatively mild conditions has been described. An electrophile-nucleophile dual activation by [Omim]Br is also discovered based on control experiments, 1H NMR and IR spectroscopies. This chemistry provides an efficient and metal-free approach for the generation of Caryl-X (XS, N, O) bonds, many of which are significant synthetic intermediates or drugs, making this methodology attractive to both synthetic and medicinal chemistry.

An efficient iron-catalyzed S-arylation of aryl and alkylthiols with aryl halides in the presence of water under aerobic conditions

Abstract In this study, an environmentally benign FeCl3·6H2O/l-proline catalytic system in the presence of TBAB was employed as a catalyst for the coupling reactions of aryl halides with aryl and alkyl thiols in water under aerobic conditions. The versatility, low cost, and environmental friendliness, in combination with high yields, makes the procedure noteworthy. This protocol offers a simple and efficient thioetherification method for aryl halides.

No-carrier-added [18F]fluoroarenes from the radiofluorination of diaryl sulfoxides

No-carrier-added [18F]fluoroarenes were synthesized through the radiofluorination of diaryl sulfoxides with [18F]fluoride ion. Diaryl sulfoxides bearing a para electron-withdrawing substituent readily gave the corresponding 4-[18F]fluoroarenes in high RCYs. This process broadens the scope for preparing novel 18F-labeling synthons and PET radiotracers.

NOVEL SPIROINDOLINE COMPOUNDS

This invention relates to novel spiroindoline compounds of formula (I) that are generally useful as medicaments, more specifically as medicaments for animals. The medicament can preferably be used for the treatment of helminth infections and the treatment of parasitosis, such as caused by helminth infections. This invention also relates to uses of the compounds to make medicaments and treatments comprising the administration of the compounds to animals in need of the treatments. This invention also relates to the preparation of said compounds. Moreover this invention relates to pharmaceutical compositions and kits comprising the compounds.

1,2,3,4,5,6-HEXAHYDROAZEPINO[4,5-B]INDOLES CONTAINING ARYLSULFONES AT THE 9-POSITION

The present invention discloses radioligands of 9-arylsulfone of the formula (I), or a pharmaceutically acceptable salt or enantiomer thereof, which are useful in diagnosing depression, obesity and other CNS disorders.

Preparation process of fluorine substituted aromatic compound

A preparation process of a fluorine substituted aromatic compound comprising reacting an alkali metal or alkali earth metal salt of an aromatic compound having a hydroxy group with an organic fluorinating agent is disclosed. As a representative fluorinating agent, a bis-dialkylamino-difluoromethane compound, for example, 2,2′-difluoro-1,3-dimethylimidazolidine, is exemplified. According to the process, an industrially useful fluorinated aromatic compound, for example, a fluorobenzene, a fluorine substituted benzophenone, a fluorine substituted diarylsulfone can be prepared with ease in economy without specific equipment.