2213-79-8

Usage

Uses

Used in Pharmaceutical Industry:
METHYL 2-CHLORO-3,5-DINITROBENZOATE is used as a chemical intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and improving existing ones.
Used in Dye Industry:
It is used as a chemical intermediate in the production of dyes, enhancing the color properties and stability of the dyes in various applications.
Used in Agrochemical Industry:
METHYL 2-CHLORO-3,5-DINITROBENZOATE is used as a chemical intermediate in the synthesis of agrochemicals, aiding in the development of effective pesticides and other agricultural products.
Used in Organic Chemical Synthesis:
It is used as a reagent in organic chemical synthesis, facilitating various chemical reactions and contributing to the production of a wide range of organic compounds.
Used in Preparation of Other Valuable Compounds:
METHYL 2-CHLORO-3,5-DINITROBENZOATE is used as a precursor in the preparation of other valuable compounds, expanding its applications in various chemical and industrial processes.

InChI:InChI=1/C8H5ClN2O6/c1-17-8(12)5-2-4(10(13)14)3-6(7(5)9)11(15)16/h2-3H,1H3

Upstream product

• 22633-33-6 methyl-3,5-dinitrosalicylate 
• 98-59-9 p-toluenesulfonyl chloride 
• 67-56-1 methanol 
• 2497-91-8 2-chloro-3,5-dinitrobenzoic acid 
• 42747-54-6 2-chloro-3,5-dinitrobenzoyl chloride 

Downstream Products

• 100541-90-0 2-(2-amino-phenylsulfanyl)-3,5-dinitro-benzoic acid methyl ester 
• 106883-45-8 2-(2-hydroxy-5-methyl-anilino)-3,5-dinitro-benzoic acid methyl ester 
• 13180-91-1 2-Isopropylideneaminooxy-3,5-dinitro-benzoic acid methyl ester 
• 13180-87-5 2-Cyclohexylideneaminooxy-3,5-dinitro-benzoic acid methyl ester 
• 13180-88-6 2-[1-(2,6-Dichloro-phenyl)-meth-(Z)-ylideneaminooxy]-3,5-dinitro-benzoic acid methyl ester 
• 13180-90-0 2-[1-(2-Methoxy-phenyl)-meth-(Z)-ylideneaminooxy]-3,5-dinitro-benzoic acid methyl ester 
• 13356-97-3 2-[1-(4-Chloro-3-nitro-phenyl)-meth-(Z)-ylideneaminooxy]-3,5-dinitro-benzoic acid methyl ester 
• 61101-42-6 2-[1-(3,5-Dibromo-4-hydroxy-phenyl)-meth-(Z)-ylideneaminooxy]-3,5-dinitro-benzoic acid methyl ester 
• 13180-89-7 2-[1-(2-Chloro-phenyl)-meth-(E)-ylideneaminooxy]-3,5-dinitro-benzoic acid methyl ester 
• 33446-02-5 2-(3-ethoxycarbonylmethyl-4-methyl-3H-thiazol-2-ylidenemethyl)-3,5-dinitro-benzoic acid methyl ester 
• 13180-86-4 2-[1-(4-Chloro-phenyl)-meth-(Z)-ylideneaminooxy]-3,5-dinitro-benzoic acid methyl ester 
• 83907-90-8 Methyl-2-(4-methyl-1-piperazinyl)-3,5-dinitrobenzoate 
• 50709-69-8 2-(2,4-dinitrophenyl)-4-isopropyl-2-phenyl-5(2H)-oxazolone 
• 110315-04-3 4-<2-(methoxycarbonyl)-4,6-dinitrophenyl>-2-(4-methoxyphenyl)-4-phenyl-5(4H)-oxazolone 

Relevant academic research and scientific papers

Synthesis and evaluation of new dinitrobenzamide mustards in human prostate cancer

Tumor hypoxia has been widely explored over the years as a diagnostic and therapeutic marker. Herein, we have reported the design and synthesis of a series of dinitrobenzamide mustards (DNBM) based on the PR-104A hypoxia-selective prodrug. Specifically, we explored the impact of various leaving groups and the introduction of a carboxylic acid group on the biological performance of the DNBM constructs. Once in hand, the Log D values, cytotoxicity in PC-3 and DU-145 human prostate cancer cells lines and the hypoxia selectivities of the DNBM analogs were examined. Overall, the DNBM constructs were found to be tolerant to modifications with none of the explored modifications substantially degrading the cytotoxic potential of the constructs.

Preparation of substituted methyl o-nitrophenyl sulfides

The nucleophilic substitution of substituted o-nitrochlorobenzenes with substituted methanethiolates, catalysed with triethylamine or pyridine, has been used to prepare a series of appropriately substituted methyl-o- nitrophenylsulfides. The prepared compounds were identified by their 1H- and 13C-NMR spectra. The base catalysed ring closure of methyl 2-(methoxycarbonylmethylsulfanyl)-3,5-dinitrobenzenecarboxylate only results in an attack of carbanion on the ester group, not on a nitro group as with the other compounds prepared. The cyclisation product is methyl 3-hydroxy-5,7-dinitro-benzo[b]thiophene-2-carboxylate (11).