7251-28-7Relevant articles and documents
Synthesis, spectral analysis and antibacterial evaluation of 5-substituted-1,3,4-oxadiazol-2-yl 4-(4-methylpiperidin-1-ylsulfonyl)benzyl sulfides
Aziz-Ur-Rehman,Ahtzaz, Samreen,Abbasi, Muhammad Athar,Siddiqui, Sabahat Zahra,Rasool, Shahid,Ahmad, Irshad
, p. 3370 - 3375 (2017/05/22)
Owing to valuable biological activities of 1,3,4-oxadiazole, sulfamoyl and piperidine functionalities, some new 1-(4-{[(5-substituted-1,3,4-oxadiazol-2-yl) thio]methyl}benzene sulfonyl)-4-methylpiperidine (6a-o) derivatives have been introduced. The target molecules were synthesized from different aralkyl/aryl carboxylic acids, 1a-o, through a series of steps. First the compounds, 1a-o, were converted to heterocyclic 1,3,4-oxadiazole nucleophiles, 4a-o. Second an electrophile as 1-(4-bromomethylbenzenesulfonyl)-4-methylpiperidine (5) was synthesized from 4-methylpiperidine. Finally the target compounds, 6a-o, were prepared by reacting 4a-o with 5 in DMF and LiH. The final compounds were structurally elucidated by spectral data of IR, 1H-NMR and EI-MS. All the compounds were screened for their antibacterial evaluation and found to exhibit valuable results.
Displacement-Cyclization Reactions of Mono-substituted Hydrazines With Chloronitrobenzenes and Chloronitropyrimidines. New Routes to 8-Azapurine and Benzopyrazole Derivatives
DeFusco, A.A.,Strauss, M.J.
, p. 351 - 355 (2007/10/02)
Reactions of different chloronitrobenzenes and chloronitropyrimidines with monosubstituted hydrazines, R-NHNH2, where R is methyl, carbomethoxy and phenyl, are described.The reactivity of these hydrazines in displacement -ortho substituent cyclizations va
