249762-27-4

Basic information

• Product Name: bis(1-benzenesulfonyl-1H-indol-2-yl)methanol
• Synonyms: bis(1-benzenesulfonyl-1H-indol-2-yl)methanol
• CAS NO: 249762-27-4
• Molecular Weight: 542.636
• Mol File: 249762-27-4.mol

Chemical Properties

• CAS DataBase Reference: bis(1-benzenesulfonyl-1H-indol-2-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: bis(1-benzenesulfonyl-1H-indol-2-yl)methanol(249762-27-4)
• EPA Substance Registry System: bis(1-benzenesulfonyl-1H-indol-2-yl)methanol(249762-27-4)

Safety Data

• Hazardous Substances Data: 249762-27-4(Hazardous Substances Data)

Upstream product

• 40899-71-6 1-benzenesulfonylindole 
• 80360-23-2 1-(phenylsulfonyl)-1H-indole-2-carbaldehyde 

Downstream Products

• 249762-94-5 bis(1-benzenesulfonyl-1H-indol-2-yl)methane 
• 249763-10-8 2-benzyloxymethyl-8-(2-(N,N-dimethylamino)ethyl)-1,2,3,8,9,10-hexahydroindolo[3',2':5,6]pyrrolo[3',4':3,4]cyclohepta[b]indole-1,3-dione 
• 249763-07-3 2-benzyloxymethyl-1,2,3,8,9,10-hexahydroindolo[3',2':5,6]pyrrolo[3',4':3,4]cyclohepta[b]indole-1,3-dione 
• 249762-39-8 bis(1-phenylsulfonyl-1H-2-indolyl)methanone 

Relevant articles and documents

Homoarcyriaflavin: Synthesis of Ring-Expanded Arcyriaflavin Analogues

The construction of the ring-expanded carbazole system, forming arcyriaflavin homologues, is efficiently accomplished by the reaction of 2,2′-bridged bis-indoles with 3,4-dibromo-2,5-dihydro-1H-2,5-pyrroledione derivatives under Grignard conditions. A ring size of up to nine members in the central ring is achievable. Substitutions either at the indole system or at the imide-N are also possible. The conformation of homoarcyriaflavins as a cross-link between the rigid arcyriaflavins and the flexible arcyriarubins was investigated by NMR, X-ray, and semiempiric quantum chemical calculation methods.

Enhancement of chemically-induced HL-60 cell differentiation by 3,3′-diindolylmethane derivatives

3,3′-Diindolylmethane (DIM, 1) and its derivatives have been prepared, and their enhancing effects on chemically-induced HL-60 cell differentiation were analyzed. Among the prepared compounds, IndDIM (12) showed the most potent enhancing effect on HL-60 cell differentiation induced by chemicals, including retinoids, 1,25-dihydroxyvitamin D3, 12-O-tetradecanoyl phorbol-13-acetate and dimethyl sulfoxide.

Indole derivatives and their use for the treatment of malignant and other diseases based on pathological cell proliferation

The invention relates to tyrosine kinase inhibitors of the bis-indolyl compound type of the general formula I: pharmaceuticals containing them and their use for the treatment of malignant and other diseases based on pathological cell proliferation.