249763-07-3Relevant academic research and scientific papers
Homoarcyriaflavin: Synthesis of Ring-Expanded Arcyriaflavin Analogues
Mahboobi, Siavosh,Burgemeister, Thomas,Dove, Stefan,Kuhr, Sabine,Popp, Alfred
, p. 8130 - 8137 (2007/10/03)
The construction of the ring-expanded carbazole system, forming arcyriaflavin homologues, is efficiently accomplished by the reaction of 2,2′-bridged bis-indoles with 3,4-dibromo-2,5-dihydro-1H-2,5-pyrroledione derivatives under Grignard conditions. A ring size of up to nine members in the central ring is achievable. Substitutions either at the indole system or at the imide-N are also possible. The conformation of homoarcyriaflavins as a cross-link between the rigid arcyriaflavins and the flexible arcyriarubins was investigated by NMR, X-ray, and semiempiric quantum chemical calculation methods.
