249762-39-8

Upstream product

• 40899-71-6 1-benzenesulfonylindole 
• 342405-28-1 1-phenylsulfonyl-1H-2-indolecarboxylic acid chloride 
• 80360-23-2 1-(phenylsulfonyl)-1H-indole-2-carbaldehyde 
• 249762-27-4 bis(1-benzenesulfonyl-1H-indol-2-yl)methanol 

Downstream Products

• 249763-10-8 2-benzyloxymethyl-8-(2-(N,N-dimethylamino)ethyl)-1,2,3,8,9,10-hexahydroindolo[3',2':5,6]pyrrolo[3',4':3,4]cyclohepta[b]indole-1,3-dione 
• 249763-07-3 2-benzyloxymethyl-1,2,3,8,9,10-hexahydroindolo[3',2':5,6]pyrrolo[3',4':3,4]cyclohepta[b]indole-1,3-dione 

Relevant academic research and scientific papers

Bis(1H-2-indolyl)methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase

The novel lead bis(1H-2-indolyl)methanone inhibits autophosphorylation of platelet-derived growth factor (PDGF) receptor tyrosine kinase in intact cells. Various substituents in the 5- or 6-position of one indole ring increase or preserve potency, whereas

Indole derivatives and their use for the treatment of malignant and other diseases based on pathological cell proliferation

The invention relates to tyrosine kinase inhibitors of the bis-indolyl compound type of the general formula I: pharmaceuticals containing them and their use for the treatment of malignant and other diseases based on pathological cell proliferation.

Homoarcyriaflavin: Synthesis of Ring-Expanded Arcyriaflavin Analogues

The construction of the ring-expanded carbazole system, forming arcyriaflavin homologues, is efficiently accomplished by the reaction of 2,2′-bridged bis-indoles with 3,4-dibromo-2,5-dihydro-1H-2,5-pyrroledione derivatives under Grignard conditions. A ring size of up to nine members in the central ring is achievable. Substitutions either at the indole system or at the imide-N are also possible. The conformation of homoarcyriaflavins as a cross-link between the rigid arcyriaflavins and the flexible arcyriarubins was investigated by NMR, X-ray, and semiempiric quantum chemical calculation methods.