2498-25-1

Usage

Uses

1. As a reagent in organic synthesis, particularly for the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
2. As a building block for the preparation of various organic compounds, including amines, amides, and esters.
3. In the synthesis of chiral compounds, as it can act as a chiral auxiliary or a chiral ligand in asymmetric catalysis.
4. As a starting material for the preparation of other functionalized alcohols and amines.
5. In the synthesis of biologically active compounds, such as alkaloids, peptides, and nucleosides.
Safety and handling:
1. 2-(Dimethylamino)-ethanol hydrochloride should be handled in a well-ventilated area, as it can release irritating vapors.
2. It is recommended to wear appropriate personal protective equipment (PPE), such as gloves, safety goggles, and a lab coat, when handling 2-(DIMETHYLAMINO)-ETHANOL HYDROCHLORIDE.
3. In case of contact with skin or eyes, immediately rinse with plenty of water and seek medical attention if necessary.
4. Dispose of the compound according to local regulations and guidelines for hazardous materials.

InChI:InChI=1/C4H11NO.ClH/c1-5(2)3-4-6;/h6H,3-4H2,1-2H3;1H

Upstream product

• 108-01-0 2-(N,N-dimethylamino)ethanol 
• 90-99-3 diphenylchloromethane 
• 3685-84-5 meclofenoxate hydrochloride 
• 4359-97-1 2,6-di-tert-butyl-4-(3,5-di-tert-butyl-4-hydroxy-benzylidene)-cyclohexa-2,5-dienone 

Downstream Products

• 108-01-0 2-(N,N-dimethylamino)ethanol 
• 4359-97-1 2,6-di-tert-butyl-4-(3,5-di-tert-butyl-4-hydroxy-benzylidene)-cyclohexa-2,5-dienone 
• 148981-62-8 (R)-(+)-Cizolirtine 
• 233753-18-9 2,5-Bis[3-(N,N-dimethylamino)-1-oxapropyl]-1,4-dibromobenzene 

Relevant academic research and scientific papers

End-to-end continuous flow synthesis and purification of diphenhydramine hydrochloride featuring atom economy, in-line separation, and flow of molten ammonium salts

A continuous end-to-end synthesis and purification of diphenhydramine hydrochloride featuring atom economy and waste minimization is described. Combining a 1:1 molar ratio of the two starting material streams (chlorodiphenylmethane and N,N-dimethylaminoethanol) in the absence of additional solvent at high temperature gives the target compound directly as a molten salt (ionic liquid above 168 °C) in high yield. This represents the first example of continuous active pharmaceutical ingredient (API) production in this manner. Six of the twelve principles of green chemistry as defined by the American Chemical Society are achieved, most prominently waste minimization and atom economy.

Temperature and Pressure Effects on the Reversible Reaction of a Parent Phenol (GH) Corresponding to Galvinoxyl with Aliphatic Amines

The effects of temperature and pressure on the reversible reaction between GH and aliphatic amines in acetonitrile have been studied spectrophotometrically.The formation of the free ions rather than that of ion pairs has been confirmed by the modified Benesi-Hildebrand (B-H) plot.From the plot the equilibrium constants were estimated.From the temperature dependence of the equilibrium constant (K), the heat and entropy of reactions were estimated to be: (ΔH0)av=-44.5 kJ mol-1, and (ΔS0)av=-193 J K-1 mol-1.From the pressure dependence of K the reaction volume (ΔV0)av was estimated to be -40 dm3 mol-1.When unbranched primary amines were used, a side reaction took place for which an explanation has been given.

Stability of solid dosage forms. II. Hydrolysis of meclofenoxate hydrochloride in commercial tablets

The kinetics of hydrolysis of meclofenoxate hydrochloride (MF-HCl) in commercial tablets were studied in comparison with those of the pure solid. MF-HCl in tablets was found to be decomposed by water vapor in the same way as the pure solid. At a humidity above the critical relative humidity (CRH) of the system, the degradation ratio, x could be correlated to time by the equation: x = kt(n) where k and n are parameters. At humidities below the CRH, on the other hand, the degradation did not conform to this equation because of the fast decomposition at the initial stage. The stability of several commercial MF-HCl tablets was studied, and some excipients such as magnesium carbonate were found to reduce the stability of the drug.