4359-97-1Relevant articles and documents
Substituent effect on the radical scavenging activity of 6-chromanol derivatives
Inami, Keiko,Suzuki, Mariko,Shimizu, Azusa,Furukawa, Miyuki,Morita, Mine,Mochizuki, Masataka
, p. 43882 - 43889 (2014)
Several 6-chromanol derivatives with various substituents (one or two amino, acetylamino, chloro or nitro substituents at the 5-, 7-, 8- or 5,7-positions on the phenyl ring of 2,2-dimethyl-6-chromanol) were synthesized, and their second order rate constan
Digiacomo,Kuivila
, p. 251,257 (1973)
Galvinoxyl radicals: Synthesis of new derivatives, determination of low oxygen contents, and stability studies
Lampp, Lisa,Azarkh, Mykhailo,Drescher, Malte,Imming, Peter
, p. 2737 - 2747 (2019)
Two new derivatives of galvinoxyl (1), a perdeutered (2) and an adamantyl-analog (3) for potential applications as spin probes were synthesized. The synthesis with deuterated educts yielded 2 with 98% D. It exhibited an 18-line EPR spectrum in octanol wit
Effect of methyl substitution on the antioxidative property and genotoxicity of resveratrol
Fukuhara, Kiyoshi,Nakanishi, Ikuo,Matsuoka, Atsuko,Matsumura, Tomohiro,Honda, Sachiko,Hayashi, Mikiko,Ozawa, Toshihiko,Miyata, Naoki,Saito, Shinichi,Ikota, Nobuo,Okuda, Haruhiro
, p. 282 - 287 (2008/12/22)
Resveratrol (trans-3,4′,5-trihydroxystilbene) is a natural phytoalexin with various biological activities including inhibition of lipid peroxidation and free radical scavenging properties. In addition to its beneficial effects, resveratrol also has significant genotoxicity that leads to a high frequency of chromosome aberration together with micronucleus and sister chromatid exchanges. To enhance the radical scavenging activities and to reduce the genotoxicity of resveratrol, we designed 4′-methyl resveratrol analogues where a methyl group was introduced at the ortho position relative to the 4′-hydroxy group, which is responsible for both antioxidative activities and genotoxicity of resveratrol. These synthesized methyl analogues of resveratrol showed increased antioxidative activities against galvinoxyl radical as an oxyl radical species. Furthermore, the methyl analogues also surprisingly showed reduced in vitro genotoxicities, suggesting that methyl substitution may improve resveratrol efficacy.