250386-15-3

Usage

Uses

Used in Medical Imaging:
ATL 146e is used as an adjunct to nuclear myocardial perfusion imaging for patients who cannot exercise adequately. It helps to improve the diagnostic accuracy of the imaging procedure by enhancing the visualization of blood flow in the heart muscle.
Used in Cardiology:
ATL 146e is used in cardiology to assess the blood flow in the heart muscle and identify areas of reduced perfusion. This information can be valuable for diagnosing and managing various heart conditions, such as coronary artery disease.
Used in Pharmaceutical Industry:
ATL 146e is used in the pharmaceutical industry for the development of new drugs targeting the A2A adenosine receptor. Its agonistic properties make it a promising candidate for the treatment of various cardiovascular and inflammatory disorders.

InChI:InChI=1/C23H30N6O6/c1-3-25-21(32)18-16(30)17(31)22(35-18)29-11-26-15-19(24)27-14(28-20(15)29)6-4-5-12-7-9-13(10-8-12)23(33)34-2/h11-13,16-18,22,30-31H,3,5,7-10H2,1-2H3,(H,25,32)(H2,24,27,28)/t12?,13?,16?,17?,18-,22+/m0/s1

Upstream product

• 141018-29-3 2-iodo-5'-N-ethylcarboxamidoadenosine 
• 329788-70-7 ((1R,4R)-4-(((tert-butyldimethylsilyl)oxy)methyl)cyclohexyl)methyl 4-methylbenzenesulfonate 
• 180046-62-2 (±)-trans-[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)cyclohexyl]methanol 
• 250682-80-5 4-prop-2-ynylcyclohexanecarboxylic acid 
• 250682-79-2 (4-prop-2-ynylcyclohexyl)methanol 
• 3236-48-4 trans-1,4-Cyclohexanedimethanol 
• 250682-81-6 methyl 4-prop-2-ynylcyclohexanecarboxylate 

Relevant academic research and scientific papers

Cyclic AMP-dependent inhibition of human neutrophil oxidative activity by substituted 2-propynylcyclohexyl adenosine A2A receptor agonists

1. Novel 2-propynylcyclohexyl-5′-N-ehtylcarboxamidoadenosines, trans-substituted in the 4-position of the cyclohexyl ring, were evaluated in binding assays to the four subtypes of adenosine receptors (ARs). Two esters, 4-{(3-[6-amino-9-(5-ethylcarbamoyl-3

Design, synthesis, and evaluation of novel A2A adenosine receptor agonists

We have been interested in the design, synthesis, and evaluation of novel adenosine A2A agonists. Through the use of comparative molecular field analysis (CoMFA) we have generated a training model that includes 78 structurally diverse A2A

Synthesis of [1,2-3H]ethylamine hydrochloride and [ 3H]-labeled apadenoson for a human ADME study

Tritium-labeled [1,2-3H]ethylamine hydrochloride was prepared through a multiple-step sequence in high radioactive specificity. The labeled amine was isolated in high purity following cartridge filtration and used subsequently in the synthesis

INDUCTION OF PHARMACOLOGICAL STRESS WITH ADENOSINE RECEPTOR AGONISTS

A method is provided employing A2A adenosine receptor agonists as vasodilators to detect the presence and assess the severity of coronary artery stenosis.