2505-31-9

Usage

Uses

Used in Plastics Industry:
2,4,6-TRICHLOROPHENYL ISOCYANATE is used as a monomer in the production of certain types of plastics. Its reactivity allows for the creation of durable and versatile plastic materials that can be tailored for specific applications.
Used in Pesticides Industry:
In the pesticides industry, 2,4,6-TRICHLOROPHENYL ISOCYANATE is used as a key intermediate in the synthesis of various agrochemicals. Its incorporation contributes to the development of effective pest control agents that protect crops from damage.
Used in Pharmaceutical Industry:
2,4,6-TRICHLOROPHENYL ISOCYANATE is utilized as a building block in the synthesis of pharmaceutical compounds. Its reactivity enables the creation of new drug molecules with potential therapeutic applications.

InChI:InChI=1/C7H2Cl3NO/c8-4-1-5(9)7(11-3-12)6(10)2-4/h1-2H

Upstream product

• 75-44-5 phosgene 
• 634-93-5 2,4,6-trichloroaniline 
• 201230-82-2 carbon monoxide 
• 18708-70-8 2,4,6-trichloronitrobenzene 
• 7782-50-5 chlorine 
• 103-71-9 phenyl isocyanate 
• 102-07-8 bis(diphenyl)urea 
• 632-22-4 tetramethylurea 
• 32315-10-9 bis(trichloromethyl) carbonate 

Downstream Products

• 115719-83-0 (2,4,6-trichloro-phenyl)-carbamic acid methyl ester 
• 99419-71-3 N-phenyl-N'-(2,4,6-trichloro-phenyl)-urea 
• 20632-35-3 bis(2,4,6-trichlorodiphenyl)urea 
• 40397-50-0 2-Hydroxy-6-oxo-cyclohex-1-enecarboxylic acid (2,4,6-trichloro-phenyl)-amide 
• 40397-52-2 2-Hydroxy-4,4-dimethyl-6-oxo-cyclohex-1-enecarboxylic acid (2,4,6-trichloro-phenyl)-amide 
• 16311-61-8 3-(2,4,6-trichlorophenyl)-2,4(1H,3H)-quinazolinedione 
• 1449005-86-0 1-{4-[(4-amino-5-thioxo-4,5-dihydro-1H-1,2,4-triazole-3-yl)methyl]phenyl}-3-(2,4,6-trichlorophenyl)urea 
• 1449005-76-8 (4-{[(2,4,6-trichlorophenyl)carbamoyl]amino}phenyl)acetic acid 
• 1391917-09-1 C₁₃H₉Cl₃N₂O₂ 

Relevant academic research and scientific papers

N-substituted 2-isonicotinoylhydrazinecarboxamides-new antimycobacterial active molecules

This report presents a new modification of the isoniazid (INH) structure linked with different anilines via a carbonyl group obtained by two synthetic procedures and with N-substituted 5-(pyridine-4-yl)-1,3,4-oxadiazole-2-amines prepared by their cyclisation. All synthesised derivatives were characterised by IR, NMR, MS and elemental analyses and were evaluated in vitro for their antimycobacterial activity against Mycobacterium tuberculosis H37Rv, Mycobacterium avium 330/88, Mycobacterium kansasii 235/80 and one clinical isolated strain of M. kansasii 6509/96. 2-Isonicotinoyl-N-(4- octylphenyl)hydrazinecarboxamide displayed an in vitro efficacy comparable to that of INH for M. tuberculosis with minimum inhibitory concentrations (MICs) of 1-2 μM. Among the halogenated derivatives, the best anti-tuberculosis activity was found for 2-isonicotinoyl-N-(2,4,6-trichlorophenyl) hydrazinecarboxamide (MIC = 4 μM). In silico modelling on the enoyl-acyl carrier protein reductase InhA confirmed that longer alkyl substituents are advantageous for the interactions and affinity to InhA. Most of the hydrazinecarboxamides, especially those derived from 4-alkylanilines, exhibited significant activity against INH-resistant nontuberculous mycobacteria. gfjh+l;kfldf.

Specific inhibitors of puromycin-sensitive aminopeptidase with a 3-(halogenated phenyl)-2,4(1H,3H)-quinazolinedione skeleton

Specific puromycin-sensitive aminopeptidase (PSA) inhibitors with a 3-(halogenated phenyl)-2,4(1H,3H)-quinazolinedione skeleton were prepared and their structure-activity relationships were investigated. The nature (F, Cl or Br), number and position(s) of the halogen atom(s) introduced into the 3-phenyl group were concluded to be critical determinants of the inhibitory activity.

Polyhalogenated phenyl isocyanate synthesis with excess phosgene and either triethylamine or tetramethylurea

Two procedures are described that can be used to prepare polyhalogenated phenyl isocyanates (2,4,6-trichloro,2,3,5,6-tetrachloro, pentachloro, 2,4,6-tribromo and 2,4,6-trifluoro derivatives) from the corresponding anilines in good yields (95-99%) with sma