25059-70-5

Basic information

• Product Name: (2-Chloroethyl)diMethylsulfoniuM iodide
• Synonyms: (2-Chloroethyl)diMethylsulfoniuM iodide;(2-CHLOROETHYL)DIMETHYLSULFANIUM IODIDE
• CAS NO: 25059-70-5
• Molecular Formula: C₄H₁₀ClS*I
• Molecular Weight: 252.54467
• Mol File: 25059-70-5.mol
• Article Data: 7

Chemical Properties

• Melting Point: 90-91 °C
• Appearance: /
• CAS DataBase Reference: (2-Chloroethyl)diMethylsulfoniuM iodide(CAS DataBase Reference)
• NIST Chemistry Reference: (2-Chloroethyl)diMethylsulfoniuM iodide(25059-70-5)
• EPA Substance Registry System: (2-Chloroethyl)diMethylsulfoniuM iodide(25059-70-5)

Safety Data

• Hazardous Substances Data: 25059-70-5(Hazardous Substances Data)

Upstream product

• 542-81-4 sulfure de methyle et de 2-chloroethyle 
• 74-88-4 methyl iodide 

Downstream Products

• 132876-84-7 2,4-dichlorophenyl 1-(pyridin-3-yl)-cyclopropyl ketone 
• 143306-64-3 tert-butyl 8-oxo-5-azaspiro[2.5]octane-5-carboxylate 
• 187723-31-5 C₂₁H₂₀O₃ 
• 5743-85-1 Spiro<2.6>nonan-4-one 
• 2205-98-3 spiro[2.5]octan-4-one 
• 935-61-5 Spiro<2.7>decan-4-one 

Relevant articles and documents

5-HT2C RECEPTOR AGONISTS AND COMPOSITIONS AND METHODS OF USE

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CYCLOHEXANE-1,2'-NAPHTHALENE-1',2"-IMIDAZOLE COMPOUNDS AND THEIR USE AS BACE INHIBITORS

Cyclohexane-1,2'-naphthalene-1',2''-imidazole compounds, therapeutically acceptable salts thereof, processes for preparation thereof, therapeutic uses of such compounds for treating Aβ-related pathologies such as Down's syndrome, β-amyloid angiopathy, Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration, methods of therapy using such compounds, and pharmaceutical compositions containing such compounds.

Reactions of 2-Chloroethyl sulfides: III. Mechanism of methanolysis of 2-Chloroethyl sulfides

The products and kinetics of methanolysis of 2-chloroethyl methyl sulfide, 2-chloroethyl 2-methoxyethyl sulfide, 2,2′-dichlorodiethyl sulfide, and 2-chloroethyl phenyl sulfide (at a concentration of 0.05-0.2 M) were studies by 13C NMR spectroscopy and gas-liquid chromatography. The rate of methanolysis decreases in the following series: methyl > methoxyethyl > 2-chloroethyl > phenyl. The amount of sulfonium dimers among the products decreases in the same series; the rate of dimerization of 2-chloroethyl methyl sulfide exceeds the rate of methanolysis. The reaction of 2-chloroethyl sulfides in methanol with a strong neutral nucleophile, thiourea, is of the second order. The rate constants of this reaction show a correlation with the constants σ* of substituents on the sulfur, which is similar to that found for the hydrolysis. This correlation indicates formation of intermediate ethylenesulfonium ion. Unlike the hydrolysis process, the rate-determining stage in the methanolysis is the reaction of ethylsulfonium ion with the nucleophile rather than ionization of 2-chloroethyl sulfide.