25059-70-5Relevant articles and documents
5-HT2C RECEPTOR AGONISTS AND COMPOSITIONS AND METHODS OF USE
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Page/Page column 100, (2017/02/28)
Provided in some embodiments are compounds of Formula A, as defined herein, that modulate the activity of 5-HT2C receptor. Also provided in some embodiments are methods, such as, for weight management, inducing satiety, and decreasing food intake, and for
CYCLOHEXANE-1,2'-NAPHTHALENE-1',2"-IMIDAZOLE COMPOUNDS AND THEIR USE AS BACE INHIBITORS
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Page/Page column 28, (2014/01/09)
Cyclohexane-1,2'-naphthalene-1',2''-imidazole compounds, therapeutically acceptable salts thereof, processes for preparation thereof, therapeutic uses of such compounds for treating Aβ-related pathologies such as Down's syndrome, β-amyloid angiopathy, Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration, methods of therapy using such compounds, and pharmaceutical compositions containing such compounds.
Reactions of 2-Chloroethyl sulfides: III. Mechanism of methanolysis of 2-Chloroethyl sulfides
Fomina,Vishnyakov,Glushkov
, p. 1282 - 1288 (2007/10/03)
The products and kinetics of methanolysis of 2-chloroethyl methyl sulfide, 2-chloroethyl 2-methoxyethyl sulfide, 2,2′-dichlorodiethyl sulfide, and 2-chloroethyl phenyl sulfide (at a concentration of 0.05-0.2 M) were studies by 13C NMR spectroscopy and gas-liquid chromatography. The rate of methanolysis decreases in the following series: methyl > methoxyethyl > 2-chloroethyl > phenyl. The amount of sulfonium dimers among the products decreases in the same series; the rate of dimerization of 2-chloroethyl methyl sulfide exceeds the rate of methanolysis. The reaction of 2-chloroethyl sulfides in methanol with a strong neutral nucleophile, thiourea, is of the second order. The rate constants of this reaction show a correlation with the constants σ* of substituents on the sulfur, which is similar to that found for the hydrolysis. This correlation indicates formation of intermediate ethylenesulfonium ion. Unlike the hydrolysis process, the rate-determining stage in the methanolysis is the reaction of ethylsulfonium ion with the nucleophile rather than ionization of 2-chloroethyl sulfide.