250592-89-3Relevant articles and documents
Improved method for preparing topramezone
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, (2018/07/30)
The invention discloses an improved method for preparing topramezone and belongs to the technical field of chemical synthesis. The improved method takes 3-nitro-o-xylene as a raw material and is characterized in that the topramezone is obtained through oximation reaction, ethylene cyclization, palladium carbon reduction, diazotization, aldehydelation, oxidation and condensation rearrangement reaction; under optimal conditions, the total yield is 33.7 percent, the raw material is cheap and easy to obtain, the treatment is convenient in the whole process, the yield is relatively high, and a certain significance in industrialized production is realized.