251302-03-1

Upstream product

• 130195-74-3 (1R,3R,4S)-2-[(1S)-1-phenylethyl]-2-azabicyclo[2.2.1]hept-5-ene-3-carboxylic acid methyl ester 
• 100-39-0 benzyl bromide 
• 297143-31-8 (1S,3R,4R)-2-azabicyclo[2.2.1]heptane-3-carboxylic acid methyl ester 
• 251302-01-9 (1S,3R,4R)-2-benzyl-2-azabicyclo[2.2.1]heptane-3-carboxylic acid methyl ester 
• 74-88-4 methyl iodide 

Downstream Products

• 273935-45-8 ((1S,3S,4R)-2-Benzyl-3-methyl-2-aza-bicyclo[2.2.1]hept-3-yl)-methanol 

Relevant academic research and scientific papers

2-Azanorbornyl alcohols: Very efficient ligands for ruthenium-catalyzed asymmetric transfer hydrogenation of aromatic ketones

2-Azanorbornyl-derived amino alcohols were prepared and evaluated as ligands in the Ru(II)-catalyzed asymmetric transfer hydrogenation of aromatic ketones. To improve selectivity and rate, the structure of the ligand was optimized. Acetophenone was reduced using 0.5 mol% catalyst in 40 min in 94% ee. This system was also able to reduce a wide range of aromatic ketones to the corresponding alcohols, while maintaining high enantioselectivities and yields. The effects of catalyst loading and the presence of cosolvents in the reaction vessel were examined, and a linearity study was also done.

Highly diastereoselective reaction of 2-azanorbornyl enolates with electrophiles

(matrix presented). A highly diastereoselective reaction of 2-azanorbornyl enolates with electrophiles has been studied. Deprotonation of 4 with LDA at low temperature affords the corresponding exocyclic lithium enolate 5, which reacts with different elec