297143-31-8

Usage

Stereochemistry

(1S,3R,4R)
Potential applications in drug development and bioactive molecule synthesis

Upstream product

• 542-92-7 cyclopenta-1,3-diene 
• 130195-74-3 (1R,3R,4S)-2-[(1S)-1-phenylethyl]-2-azabicyclo[2.2.1]hept-5-ene-3-carboxylic acid methyl ester 

Downstream Products

• 297143-32-9 (1S,3R,4R)-2-(4-tert-butylphenylsulfonyl)-2-azabicyclo[2.2.1]heptane-3-carboxylic acid methyl ester 
• 297143-30-7 (1S,3R,4R)-2-(p-tert-butylphenylsulphonyl)-2-aza-bicyclo[2.2.1]heptane-3-caboxylic acid 
• 553645-76-4 (1S,3R,4R)-3-(toluene-4-sulfonyloxymethyl)-2-azabicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester 
• 553645-77-5 (1S,3R,4R)-3-benzylsulfanylmethyl-2-azabicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester 
• 251302-03-1 (1S,3S,4R)-2-benzyl-2-azabicyclo[2.2.1]heptane-3-methyl-3-carboxylic acid methyl ester 
• 251302-09-7 C₅H₇CO₂CH₃NC₆H₅C₂H₄C₆H₅CHO 
• 251302-01-9 (1S,3R,4R)-2-benzyl-2-azabicyclo[2.2.1]heptane-3-carboxylic acid methyl ester 

Relevant academic research and scientific papers

MACROCYCLIC INHIBITORS OF PEPTIDYLARGININE DEIMINASES

The present disclosure relates to novel compounds for use in therapeutic treatement of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.

A rigid dirhodium(II) carboxylate as an efficient catalyst for the asymmetric cyclopropanation of olefins

The dirhodium(II) complex 7 of (1S,3R,4R)-2-(p-tert-butylphenylsulphonyl)-2-aza-bicyclo[2.2.1]heptane-3- carboxylic acid (3) (or its enantiomer) was synthesised in four steps from cyclopentadiene, (R)- or (S)-phenylethylamine and methyl glyoxylate. Comple

Highly diastereoselective reaction of 2-azanorbornyl enolates with electrophiles

(matrix presented). A highly diastereoselective reaction of 2-azanorbornyl enolates with electrophiles has been studied. Deprotonation of 4 with LDA at low temperature affords the corresponding exocyclic lithium enolate 5, which reacts with different elec