2514-36-5

Basic information

• Product Name: 1,2-Benzisothiazol-3(2H)-one, 2-(phenylmethyl)-
• CAS NO: 2514-36-5
• Molecular Formula: C14H11NOS
• Molecular Weight: 241.313
• Mol File: 2514-36-5.mol
• Article Data: 32

Chemical Properties

• CAS DataBase Reference: 1,2-Benzisothiazol-3(2H)-one, 2-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Benzisothiazol-3(2H)-one, 2-(phenylmethyl)-(2514-36-5)
• EPA Substance Registry System: 1,2-Benzisothiazol-3(2H)-one, 2-(phenylmethyl)-(2514-36-5)

Safety Data

• Hazardous Substances Data: 2514-36-5(Hazardous Substances Data)

Usage

Common Uses

Preservative in industrial and consumer products
Biocide in paints, coatings, adhesives, metalworking fluids, and water treatment chemicals

Antimicrobial

Inhibits the growth of bacteria, fungi, and algae

Potential Toxic Effects

May cause skin, eye, and respiratory irritation

Safety and Regulations

Use is regulated in certain applications
Importance of safe handling and storage to minimize exposure risks

Upstream product

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• 36665-23-3 benzo[d]-1,3-oxathiin-4-one 1-oxide 
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Downstream Products

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• 1298131-33-5 3-(2-(benzylcarbamoyl)phenylthio)prop-2-ynyl 2-chloro-5-nitrobenzoate 
• 1298131-45-9 N-benzyl-2-(thianthren-1-ylthio)benzamide 
• 1298131-38-0 3-(thianthren-1-yl)prop-2-ynyl 2-chloro-5-nitrobenzoate 
• 1298131-34-6 N-benzyl-2-(3-(1,3-dioxoisoindolin-2-yl)prop-1-ynylthio)benzamide 
• 1298131-28-8 N-benzyl-2-(p-tolylthio)benzamide 
• 1298131-42-6 N-benzyl-2-(4-formylphenylthio)benzamide 
• 1173988-46-9 N-benzyl-2-(2-methoxyphenylthio)benzamide 
• 1298131-43-7 N-benzyl-2-(3-hydroxyphenylthio)benzamide 
• 1298131-44-8 2-(1H-indol-5-ylthio)-N-benzylbenzamide 

Relevant articles and documents

Structure-Activity Studies Reveal Scope for Optimisation of Ebselen-Type Inhibition of SARS-CoV-2 Main Protease

The reactive organoselenium compound ebselen is being investigated for treatment of coronavirus disease 2019 (COVID-19) and other diseases. We report structure-activity studies on sulfur analogues of ebselen with the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro), employing turnover and protein-observed mass spectrometry-based assays. The results reveal scope for optimisation of ebselen/ebselen derivative- mediated inhibition of Mpro, particularly with respect to improved selectivity.

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Novel synthesis method of N-substituted benzisothiazoline-3-ketone derivative

The invention discloses a novel synthesis method of an N-substituted benzisothiazoline-3-ketone derivative. The preparation method comprises the following steps: by taking a dithiosalicylic acid derivative and sulfur as raw materials, introducing chlorine or bromine to obtain a halogenated thiobenzoyl halide derivative, then preferably dropwise adding a mixed solution of primary amine and tertiaryamine, and carrying out reaction and ring closing to obtain the N-substituted benzisothiazole-3-ketone. The method disclosed by the invention is simple in process, safe and controllable, and easy forindustrial large-scale production.