251658-72-7

Upstream product

• 251658-77-2 1-(4-nitrophenyl)-3-(3-pyridinyl)-5-ethylpyrazole 
• 350-03-8 methyl-3-pyridylketone 
• 251658-76-1 3-(5-ethyl-2H-pyrazol-3-yl)-pyridine 

Downstream Products

• 251655-68-2 [4-(5-Ethyl-3-pyridin-3-yl-pyrazol-1-yl)phenyl]-(2-chloro-6-fluorobenzyl)amine 
• 251655-63-7 [4-(5-ethyl-3-pyridin-3-yl-pyrazol-1-yl)phenyl]-(2-indanylmethyl)amine 
• 251655-61-5 [4-(5-Ethyl-3-pyridin-3-yl-pyrazol-1-yl)phenyl]-(2-methylbenzyl)amine 
• 251655-62-6 N-[4-(5-Ethyl-3-pyridin-3-yl-pyrazol-1-yl)phenyl]-1-methylindole-2-carboxamide 
• 251655-69-3 [4-(5-Ethyl-3-pyridin-3-yl-pyrazol-1-yl)phenyl]-[4-(3-cyanopropoxy)benzyl]-amine 
• 251655-71-7 [4-(5-Ethyl-3-pyridin-3-yl-pyrazol-1-yl)phenyl]-(2-fluoro-6-methylbenzyl)amine 

Relevant academic research and scientific papers

Substituted 1-(4-aminophenyl)pyrazoles and their use as anti-inflammatory agents

1-(4-aminophenyl)pyrazoles optionally substituted on the 3- and 5-positions of the pyrazole ring and on the amino group at the 4-position of the phenyl ring are disclosed and described, which pyrazoles inhibit IL-2 production in T-lymphocytes.

Practical synthesis of 1,3-diaryl-5-alkylpyrazoles by a highly regioselective N-arylation of 3,5-disubstituted pyrazoles with 4- fluoronitrobenzene

3-Aryl-5-alkylpyrazoles undergo a highly regioselective arylation on N-1 atom with 4-fluoronitrobenzene in the presence of base to yield the corresponding 1-(4-nitrophenyl)pyrazoles. (C) 2000 Elsevier Science Ltd.