252186-80-4

Usage

Uses

Used in Pharmaceutical Synthesis:
2,3-dichlorobenzoic acid anhydride is utilized as a key intermediate in the synthesis of pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its unique structure and reactivity enable the creation of diverse medicinal compounds with specific therapeutic properties.
Used in Agrochemical Production:
In the agrochemical industry, 2,3-dichlorobenzoic acid anhydride serves as an essential intermediate for the production of various agrochemicals. It plays a crucial role in the development of pesticides, herbicides, and other agricultural chemicals that help protect crops and enhance agricultural productivity.
Used in Organic Chemistry Research:
2,3-dichlorobenzoic acid anhydride is employed as a valuable research compound in the field of organic chemistry. Its unique structure and reactivity make it an interesting subject for studying chemical reactions, mechanisms, and the synthesis of novel organic compounds.
Used in Materials Science:
Although still under investigation, 2,3-dichlorobenzoic acid anhydride has shown potential applications in materials science. Its unique properties may contribute to the development of new materials with specific characteristics, such as improved stability, reactivity, or other desirable attributes.

Upstream product

• 2905-60-4 2,3-dichlorobenzoyl chloride 
• 143-33-9 sodium cyanide 
• 544-92-3 copper(I) cyanide 
• 773837-37-9 sodium cyanide 
• 50-45-3 2,3-dichlorbenzoic acid 

Relevant academic research and scientific papers

An Evaluation of Multiple Catalytic Systems for the Cyanation of 2,3-Dichlorobenzoyl Chloride: Application to the Synthesis of Lamotrigine

2,3-Dichlorobenzoyl cyanide is a key intermediate in the synthesis of Lamotrigine. An assessment of various catalytic systems for the cyanation of 2,3-dichlorobenzoyl chloride with cyanide salts is described. High-throughput experimentation identified many conditions for effecting the requisite chemistry, including amine bases and phase-transfer catalysts, as well as catalyst-free conditions utilizing acetonitrile as a polar cosolvent. A novel catalyst, CuBr2, was identified by consideration of the possible oxidation of Cu(I) during high-throughput screening experimentation. CuCN was found to be the best cyanide source for achieving clean conversion; however, the solubility of CuCN was the major factor limiting reaction rate under many conditions. Improving CuCN solubility by using acetonitrile as solvent enhanced the reaction rate even in the absence of the catalysts tested but significantly complicated isolation of the product. With no acetonitrile cosolvent, phase-transfer catalysts such as tetrabutylammonium bromide (TBABr) are effective; however, use of TBABr led to inconsistent reaction profiles from run-to-run, due to an unexpected clumping of the CuCN solid. Switching to cetyltrimethylammonium bromide (CTAB) alleviated this clumping behavior, leading to consistent reactivity. This CTAB-catalyzed process was scaled up, giving 560 kg of 2,3-dichlorobenzoyl cyanide in 77% isolated yield.